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1. Introduction
2. Ca2+: a simple ion for complex signaling
3. Ca2+ signaling: simplicity and complexity
4. Calcium control of cell migration
5. Ca2+ gradient in migrating immune cells
6. Paradox of Ca2+ signaling in the leading lamella
7. Experimental system
8. Flickering Ca2+ signals in migrating fibroblast
9. Patterned activation of Ca2+ flickers
10. Resting and dynamic [Ca2+]i gradients
11. Ca2+ flicker gradient opposes averaged gradient
12. Space-time activation of Ca2+ flickers
13. Unitary properties of Ca2+ flickers
14. Ca2+ flickers in rat and mouse fibroblasts
15. Ca2+ flickers in non-motile WI-38 fibroblast
16. Ca2+ channels in moving keratocytes
17. Involvement of stretch-activated cation channels
18. Ca2+ flickers decode mechanical stress
19. Ca2+ flicker from a single SACC
20. Transient receptor potential cation channels
21. Gene silencing of TRPCCs in WI-38 cells
22. TRPM7 mediates Ca2+ flickers (1)
23. TRPM7 mediates Ca2+ flickers (2)
24. Mg2+ sensitivity of TRPM7 Ca2+ flickers
25. Ca2+ release via InsP3R affects TRPM7 Ca2+ influx
26. siRNA knockdown of InsP3Rs
27. InsP3R2 modulates Ca2+ flicker amplitude
28. Integrating chemomechanical signals
29. What is the function of Ca2+ flickers?
30. Effects of homogeneous PDGF
31. Asymmetrical lamellar Ca2+ flicker activity
32. Turning distance and asymmetric flicker activity
33. Turning angle and asymmetric flicker activity
34. Mechano-chemical transduction in leading edge
35. Overlay of focal adhesions and Ca2+ flickers
36. Cytoskeletal feedback regulation of Ca2+ flickers
37. Chemotaxis under various treatments
38. Essential role of Ca2+ flickers in chemotaxis
39. Multiscaled and multilayered Ca2+ dynamics
40. Ca2+ steering the turning of fibroblasts
41. Acknowledgements (1)
42. Acknowledgements (2)
43. Acknowledgements (3)
44. Thank you

Topics Covered

• Paradox of calcium signaling in cell migration
• Calcium flickers in migrating fibroblasts
• Trigger mechanism and molecular origin of calcium flickers
• Calcium flickers steer cell turning
• Feedback loop between calcium flickers and cytoskeletal traction force generation
• Role of calcium flickers in chemotaxis
• Calcium flicker model of cell turning

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on March 26, 2012
• Archived on August 13, 2020

Financial Disclosures

• Prof. Heping Cheng has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.