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42 min
1. Historic introduction to innate immunity- Prof. Heiko Herwald
- Prof. Arne Egesten
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52 min
2. Evolution of innate immunity- Prof. Jim Kaufman
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25 min
3. The phagocytic synapse in distinguishing particulate and soluble stimuli- Prof. David Underhill
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23 min
4. How bacterial pathogens avoid phagocyte killing- Dr. Thomas Areschoug
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43 min
5. Origin of myeloid cells- Prof. Frederick A. Geissmann
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67 min
6. Dendritic cells- Prof. Muriel Moser
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38 min
7. Eosinophil biology and disorders associated with eosinophilia- Dr. Thomas B. Nutman
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60 min
8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity- Prof. Steven A. Porcelli
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50 min
9. Innate-like B cells- Prof. John F. Kearney
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58 min
10. Cytoplasmic innate immune sensors- Prof. Seth Masters
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76 min
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28 min
12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome- Prof. Robert Wilkinson
- Prof. Graeme Meintjes
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37 min
13. Antimicrobial peptides in the innate immune system of the lung- Prof. Dr. Pieter S. Hiemstra
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49 min
14. Chemokines and their receptors: their biology and therapeutic relevance- Dr. Amanda Proudfoot
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45 min
15. Heat shock proteins and their role in the immune regulation of inflammation- Prof. Willem Van Eden
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42 min
16. Tissue damage control confers host tolerance to infection- Dr. Miguel P. Soares
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22 min
17. Autophagy as a barrier to infection- Prof. Michele Swanson
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42 min
18. Innate immunity in the intestine in health and disease- Prof. Kevin Maloy
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51 min
19. Dendritic cells and the eye: their role in the ocular immune response- Prof. John V. Forrester
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26 min
20. Mononuclear phagocytes and HIV infection- Dr. Guido Poli
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41 min
21. Th17 cells and innate immunity- Prof. Mihai Netea
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37 min
22. Epigenetic regulation of innate immunity- Dr. Osamu Takeuchi
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66 min
23. Intracellular DNA sensing pathways- Prof. Veit Hornung
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52 min
24. Physiology of innate immunity- Prof. Keith W. Kelley
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49 min
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32 min
26. Regulation of type 2 immunity by basophils- Prof. David Voehringer
- Archived Lectures *These may not cover the latest advances in the field
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53 min
27. TLRs, NLRs, DAMPs and PAMPs- Prof. Luke O'Neill
Printable Handouts
Navigable Slide Index
- Introduction
- Inflammation caused by innate immunity
- Pleiotropic function of macrophages
- The concept of the macrophage subtypes (1)
- Toll-like receptors and their ligands
- Signaling pathway for IL-1/TLR family
- Post-transcriptional regulation
- Epigenetic regulation by histone modification
- Histone lysine methylation
- LPS (TLR4) stimulation
- Jmjd3 expression in response to LPS
- Jmjd3 family
- Generation of Jmjd3 knockout mice
- Jmjd3-/- mice neonatal death
- Jmjd3 and macrophages elicited by thioglycollate
- Jmjd3 and recruitment of macrophages to Listeria
- The concept of the macrophage subtypes (2)
- Chitin as an inducer of M2 macrophages
- Jmjd3 is critical for MR expression
- Jmjd3 role in M2 macrophage polarization
- Jmjd3 is critical for eosinophils recruitment
- Nippostrongylus brasiliensis infection model
- Impaired M2 macrophage marker expression
- Jmjd3 recruits eosinophils against NB infection
- Jmjd3 is critical for inducing Th2 response
- GM-CSF and M-CSF
- M-CSF M2 macrophage marker expression
- M2 macrophage marker expression
- Identification of trimethylated H3K27 (me3) loci
- H3K27me3 and gene expression correlation in WT
- H3K27me3 peak in Jmjd3-/- macrophages
- IRF4, one of the targets of Jmjd3 for demethylation
- Jmjd3 demethylase activity and IRF4 induction
- IRF4 importance to chitin administration in vivo
- M2 expression in IRF4-/- M-CSF-induced-BMM
- Retroviral expression of IRF4
- Conclusion
- Control of M2 macrophage differentiation
- Macrophage differentiation, chromatin remodeling
- Acknowledgements
Topics Covered
- The innate immune cells
- Pathogen sensing receptor system
- Histone modifications and inflammation control
- Critical role of Jmjd3, a trimethyl H3K27 specific demethylase, in M2 macrophage differentiation
- Identification of IRF4 as a Jmjd3 target gene inducing M2 macrophages
Links
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Talk Citation
Takeuchi, O. (2012, April 3). Epigenetic regulation of innate immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/2286/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Osamu Takeuchi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Epigenetic regulation of innate immunity
Published on April 3, 2012
37 min
