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1. Introduction
2. The HIV pandemic - 2010
3. HIV structure
4. HIV targets cells express CD4 & CCR5 or CXCR4
5. The HIV life cycle
6. Macrophages as "Trojan horses" of HIV virions
7. HIV infection of T cells and macrophages
8. Mononuclear phagocytes differentiation & HIV
9. HIV infects bone marrow MP precursors in vitro
10. HIV Infects bone marrow MP precursors in vivo
11. HIV affects the function of circulating monocytes
12. HIV infects circulating monocytes
13. HIV & tissue macrophages
14. HIV & the brain
15. Intestinal macrophages don't express HIV Co-R
16. Intestinal macrophages are not infectible by HIV
17. Intestinal vs. blood macrophages
18. HIV replication in myelo-monocytic cell lines
19. Promonocytic U937 & U1 cell lines (1)
20. Promonocytic U937 & U1 cell lines (2)
21. Inhibition of HIV-1 replication in minus U937 cells
22. Differential expression of HMGB1-R in U937 cells
23. Only minus U937 cell clones express TRIM22
24. Promonocytic U937 & U1 cell lines (3)
25. Differential effect of IFN-alpha and IFN-gamma (1)
26. Differential effect of IFN-alpha and IFN-gamma (2)
27. Does polarization influence susceptibility to HIV?
28. Human macrophages can be polarized
29. Polarization of monocyte-derived macrophages
30. M1 and M2a polarization inhibits HIV-1 replication
31. Functional differences between M1 and M2 MDM
32. Differential inhibitory effects of M1 vs. M2 on HIV-1
33. Conclusions
34. Acknowledgments

Topics Covered

• The HIV pandemic
• HIV structure
• HIV target cells and their viral receptors
• HIV life cycle
• Macrophages as "Trojan horses" of HIV
• Comparison of HIV infection of T cells and macrophages
• Macrophage differentiation
• HIV infection of bone marrow precursors in vitro and in vivo
• Functional defects of monocytes
• HIV and tissue macrophages
• HIV and the brain
• HIV and intestinal macrophages
• HIV replication in monocytic cell lines
• U937 and U1 cell lines
• HMGB1 and HIV infection of U937 cells
• U937 cell clones and TRIM22
• IFNs and HIV infection of macrophages
• Human macrophage polarization and HIV infection
• Macrophage polarization and inhibition of HIV replication
• Differences between M1 and M2 macrophages in inhibiting HIV replication

Links

Series:

• Cells of the Innate Immune System

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Dr. Guido Poli has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.