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• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

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Navigable Slide Index

1. Introduction
2. NKT cells
3. Innate and adaptive immune cells
4. NKT cells: definition and classification
5. Thymic development of "type 1" or iNKT cells
6. Signaling required for iNKT cell development
7. T cell antigen receptors of iNKT cells
8. Remarkable level of conservation of iNKT cell TCRs
9. CD1d basic features
10. iNKT cells: natural & synthetic glycolipid antigens
11. Alpha-GalCer cancer activity immunological basis
12. Binding of Alpha-GalCer to CD1d
13. CD1d tetramers for identification of NKT cells
14. Identification of iNKT cells in tissues
15. Phenotypic subsets of iNKT cells defined by CD4
16. Functional differences between iNKT subsets cells
17. Bacterial glycolipids recognized by NKT cells
18. What lipids are presented by CD1d to iNKT cells?
19. Comparison of foreign and self antigen by CD1d
20. Basic features of iNKT cells: review
21. What do iNKT cells do?
22. Response to strong antigenic stimulus
23. Cytokine production by human iNKT cell clone
24. iNKT cell recognition of bacterial glycolipids
25. INKT activation following infection
26. Direct versus indirect activation of iNKT cells
27. iNKT cells contribute to resistance to infection
28. Anti-cancer effects of iNKT cell activation (1)
29. Anti-cancer effects of iNKT cell activation (2)
30. Different tissue iNKT cell & anticancer activity
31. Different phenotypic subsets & anticancer activity
32. Response to weak antigenic stimulus
33. Cytokine production by NKT cell clone DN2.D5
34. Diverse potential outcomes of NKT cell activation
35. Anti-inflammatory/regulatory effects of iNKT cells
36. Reduced NKT cells levels in autoimmune diseases
37. High expression of CD1d in spleen marginal zone
38. NKT cells regulate B cells
39. Enhanced anti-PC responses after immunization
40. Lupus, MZ B cells and iNKT cells?
41. iNKT cells regulate autoreactive B cell responses
42. Therapeutic manipulation of NKT cells
43. Synthetic analogues of alpha-GalCer KRN7000
44. Alpha-GalCer analogues
45. "TH2-like" bias: C20:2 and OCH analogues
46. Prevention of autoimmune type 1 diabetes mellitus
47. Overall summary and conclusions
48. Acknowledgments

Topics Covered

• Definition of NKT cells and their relation to other innate-like lymphocytes
• Development of NKT cells
• Mechanisms of glycolipid antigen recognition by NKT cells
• Frequency and phenotype of NKT cells
• Foreign and self antigens recognized
• Proinflammatory functions (anti-infectious and anti-tumor activities)
• Anti-inflammatory and tolerance-promoting functions
• Manipulation of NKT cell responses and therapeutic opportunities

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 5, 2012

Financial Disclosures

• Prof. Steven A. Porcelli, Consultant: Vaccinex, Inc. (Rochester, NY).