• View the Talks
• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Pathogens range from viruses to parasites
3. Evolutionary arms race
4. Pathogens against which immunity must protect
5. Why is the immune response so complicated?
6. An adaptive immune system
7. Barriers, cells and molecules in innate immunity
8. Pathogen recognition receptors
9. A receptor for "stress signals"
10. "Self markers" and "missing self"
11. Innate / adaptive immunity / genetic resistance
12. A textbook view of immune responses
13. Evolutionary history of immune responses
14. A phylogenetic tree of the vertebrates
15. A phylogenetic tree of the multicellular animals
16. A phylogenetic tree of living organisms
17. Phylogenetic tree of the animals - Metazoans
18. Invertebrates survive with just innate immunity
19. Adaptive immunity in invertebrates (1)
20. Adaptive immunity in invertebrates (2)
21. Diversity in the immune system
22. A short summary, a conclusion and a caveat
23. Variation between groups of animals
24. History of innate immunity - five examples (1)
25. History of innate immunity - Toll-like receptors (1)
26. History of innate immunity - Toll-like receptors (2)
27. History of innate immunity - Toll-like receptors (3)
28. History of innate immunity - Complement
29. The complement system
30. Complement is an ancient, important system
31. Complement can detect "missing self"
32. Evolution by duplication of little modules
33. Complement components are very ancient
34. History of innate immunity - Natural Killer cells
35. NK cells: an important arm of the innate immunity
36. NK cells detect "missing self"
37. NK cells detect stress (1)
38. NK cells detect stress (2)
39. A new concept of "innate lymphocytes"
40. Innate / adaptive immunity - what came first?
41. NK receptors: different molecules, same job
42. Follow evolution of NK by signalling cascades
43. History of innate immunity: Antimicrobial peptides
44. AMPs are important for innate immunity
45. AMPs are widespread in living organisms
46. A phylogenetic tree of living organisms - AMP
47. History of innate immunity - Phagocytes
48. Macrophages are key cells for innate immunity
49. Macrophages are found throughout metazoans
50. A phylogenetic tree - Macrophages
51. History of innate immunity - five examples (2)
52. Conclusions

Topics Covered

• Evolutionary arms race between hosts and pathogens
• Evidence and models of adaptive and innate immunity
• Methods and data for inferring the evolution of immunity
• Toll-like receptors (TLRs)
• The complement system (C')
• Natural killer (NK) cells
• Anti-microbial peptides (AMPs)
• Phagocytes
• Diversity in immune responses is a most important property

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 2, 2012
• Reviewed on January 23, 2022

Financial Disclosures

• There are no commerical/financial matters to disclose.