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1. Introduction
2. Spinal cord injury image
3. Spinal cord injury: general data
4. Important points about spinal cord injury
5. Diagram of human spinal cord
6. Integrating clinical care and scientific research
7. Some history
8. SCI patients during WW1
9. Gordon Holmes and the neurological heritage
10. Donald Munro (1)
11. Donald Munro (2)
12. SCI patients during WW2
13. Stoke Mandeville hospital
14. Sir Ludwig Guttman
15. Implementing Munro's methods
16. Why was Guttmann successful?
17. What we can do now
18. Finding out function priority in patients
19. Developing better wheel chairs
20. The importance of sports to SCI patients
21. John Cavanagh
22. Sex and reproduction: male and female SCI patients
23. Examples of ejaculatory problems
24. Surgical sperm retrieval
25. Fertility program projects
26. Improving sexual function
27. Bladder hyperreflexia following spinal cord injury
28. Bladder emptying
29. The FineTech Brindley bladder control system
30. The future: protection and repair
31. Structural repair
32. The importance of neuroprotection in SCI
33. Neuroprotective treatment
34. SCI repair mechanisms: regeneration and plasticity
35. Axon regeneration in CNS and PNS
36. CNS environment is inhibitory to axon regeneration
37. Why axon regeneration in the spinal cord fails
38. Oligodendrocytes inhibit axon regeneration
39. Oligodendrocyte inhibitory factors
40. Anti Nogo A antibody (1)
41. Anti Nogo A antibody (2)
42. Trial of anti-Nogo A antibody in partial SCI monkeys
43. ATI355 for spinal cord injury
44. Axon growth from DRGs
45. Recruitment and upregulation of inhibitory factors
46. Chondroitin sulfate proteoglycan
47. Chondroitinase treatment
48. Why CNS axons fail to regenerate
49. Most adult DRG axons regenerate after axotomy
50. Most adult retinal ganglion axons do not regenerate
51. Improving intrinsic regenerative ability of axons
52. Using trophic factors for regenerating axon growth
53. Lisa McKerracher: the role of Rho in axonal growth
54. Rho signalling pathway
55. AIS changes as a function of dose
56. Plasticity as a target mechanism
57. Functional recovery depends on plasticity
58. Proteoglycan and plasticity
59. Chondroitinase treatment
60. Plasticity promotion and improved recovery (1)
61. Plasticity promotion and improved recovery (2)
62. Rehabilitation helps direct new connections
63. Specific rehabilitation task for skilled paw function
64. Effects of specific rehabilitation
65. Combining plasticity treatment and rehabilitation
66. Combined treatment: how the interaction works
67. Chondroitinase is in pre-clinical development
68. Incomplete repair with biological treatment
69. Implantation of an electrode array
70. Using implanted electrodes to control a robotic arm
71. Electrode interface problem
72. New treatments for C4 spinal cord injury
73. New treatments for C6 spinal cord injury
74. New treatments for C8 spinal cord injury
75. Today's solutions for injured patients
76. Acknowledgments

Topics Covered

• Spinal cord injury
• History of spinal cord injury research
• Needs of spinal injury patients
• Reproduction and sexual function
• Bladder function
• Neuroprotection
• Axon regeneration
• Plasticity
• Reactivation of plasticity
• Combined plasticity and rehabilitation
• Electronic restoration of function
• Clinical threshold for repair treatments

Links

Series:

• Neurotrauma

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Fawcett, J. (2012, March 15). The treatment of spinal cord injury: past, present and future [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/2270/.
Export Citation (RIS)

Publication History

• Published on March 15, 2012

Financial Disclosures

• Prof. James Fawcett has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.