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Printable Handouts
Navigable Slide Index
- Introduction
- Aims
- Global initiative for asthma (GINA)
- Beta2-agonists in asthma
- Duration of action of inhaled beta2-agonists
- LABA monotherapy in asthma
- Specific label changes for LABAs
- Glucocorticoids in asthma
- Complementary effects of LABAs and ICS
- Combination therapy in asthma
- Combination inhalers of LABA and ICS
- Scientific rationale for combination therapy
- Mechanisms of glucocorticoid action
- Effects of beta2-agonists on CS effects
- Formoterol enhances GR translocation in vivo
- LABAs increase anti-inflammatory effects of CS
- Effect of ICS on GR nuclear localisation in vivo
- Salmeterol enhances GR translocation
- Effect of beta2-agonists on GR activation
- Effects of CSs on beta2-agonist effects
- Effects of corticosteroids on beta2-receptors
- Corticosteroids enhance LABA bronchodilation
- Combination better than separate components
- Conclusions
- Thank you
Topics Covered
- Asthma treatment guidelines
- Pharmacology of inhaled corticosteroids and long-acting beta agonists
- Clinical evidence for combination therapy in asthma
- Molecular interactions between inhaled corticosteroids and long-acting beta agonists
Links
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Talk Citation
Usmani, O.S. (2012, February 19). Inhaled corticosteroids and beta2-agonists [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/AVTX6003.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Omar S. Usmani, Speaker’s bureau: Takeda, Chiesi ; Grant/Research Support (Principal Investigator): Chiesi, GSK, Astra Zeneca, Takeda.