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Hi, I'm Linda Hendershot,
The Department of Tumor Cell Biology at
St. Jude Children's Research Hospital in Memphis, Tennessee.
I'll be talking about the chaperon systems of the endoplasmic reticulum.
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The ability of cells to communicate with each other and their environment in
specific ways is essential to survival in multicellular organisms.
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One of the primary ways this is done is through proteins
expressed on the cell surface or secreted from the cell.
For example, a damaged cell or tumor cell,
which requires additional nutrients or oxygen,
has the ability to secrete pro-angiogenic factors which will bind to
endothelial cells and stimulate the production of
blood vessel and oxygen flow to the tumor cell.
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Another example is direct cell to cell communication.
For example, a virus-infected cell is recognized by
a T-cell of the immune system by an antigen is expressed on the cell surface,
which can induce the T-cells to kill the virus-infected cell.
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Another example is the secretion of effector molecules like antibodies from plasma cells,
which can target bacteria for destruction.
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Another example is the use of proteins for cellular communication can be seen
in the migration of cells throughout the body or homing into specific tissues.
For example, a B cell,
which can be synthesized in the fetal liver or in the bone marrow,
was turned to a lymph node,
which occurs at the expression of proteins on
the B cell surface that interacts with proteins on the surface of the lymph node.
The cell surface and secreted proteins are
