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Printable Handouts
Navigable Slide Index
- Introduction
- The human skeletal system
- Thesis
- Bone circulation
- IOP measurement: 40 years ago
- IOP wave forms
- Effect of drug administration on IOP measurement
- Effect of clamping supplying artery on IOP measurement
- Effect of clamping draining vein on IOP measurement
- IOP variation – but why?
- Effect of needle tip contact area
- Pulse volume and IOP
- IOP change vs. initial IOP after clamping the femoral artery
- Significance of IOPv - IOPa
- Replace, Reduce, Refine (3Rs)
- Loading: Static fixator or ‘walking’
- Load
- Pressure loading in the joints
- Alteration to the study model: Replace, reduce, refine (3Rs)
- Walking load +/- perfusion
- MRI scan: Distal femur
- MRI anatomy: Upper tibial vascular marks
- MRI scan: Just under the joint surface
- MRI scan: Moving down form the joint surface
- Vascular markings by 3.3mm layers below tibial surface
- X-ray and MRI study
- Correlation between vascular marks and Kellgren - Lawrence grade
- Vascular marks decrease with increasing osteoarthritis
- Anatomy
- Blue dye injection into bone
- Morphology: Macro/micro
- Axial vessels
- Choke valves?
- Nomral vs. arthritic joint
- Conclusions (1)
- Conclusions (2)
- Conclusions (3)
- Conclusions (4)
- Summary
- For further reading
- Financial disclosures
Topics Covered
- Joints
- IOP measurement
- Factor affecting IOP measurements
- Significance of IOPv
- IOPa
- Load
- Vascular markings in MRI scans
- Correlation between vascular marks and Kellgren
- Lawrence grade
- Bone histology
- Choke valve
Links
Categories:
Therapeutic Areas:
Talk Citation
Beverly, M. (2026, September 30). Walking on water: load bearing, joint perfusion and osteoarthritis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 1, 2026, from https://doi.org/10.69645/WALA1347.Export Citation (RIS)
Publication History
- Published on September 30, 2026
Financial Disclosures
- There are no commercial or other vested interests in this work and Dr. Beverly has none elsewhere.
A selection of talks on Physiology & Anatomy
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. I'm Michael Beverly,
an orthopaedic surgeon.
I'd like to tell you something
about walking on water,
or at least load-bearing,
joint perfusion and why
you get osteoarthritis.
0:16
Well, we all have a skeleton,
and that has a
number of functions.
For example, producing red cells
and the calcium
store, but mainly,
we use our skeletons
for walking about,
assisted by joints.
Of course, those are
beautifully lubricated
cartilage ends bathed
in a synovial fluid
which gives it such a great
mechanical advantage.
But bone is a living tissue.
Each bone has arteries and
veins and a blood supply.
The problem mainly is
with orthopaedic surgeons
who believe bone is like wood.
You can saw or drill, or plate,
or bang a nail down it or
even replace the whole joint.
1:01
But I want to alter your
thinking about that.
Here is a thesis.
Bone is a living tissue.
It's micro-flexible,
and it's perfused
with a blood supply.
When it's loaded,
enormous pressures
arise just under the joint
surfaces, and that force
or pressure is transferred
by hydraulic means
through the liquid fat
under the joint surfaces
and onto the shaft of the bone.
If you accept that and look
for changes in the vessels,
you will find they're beautifully
modified to cope with
this hydraulic or dynamic
vascular mechanical system.
When that fails, it
contributes to osteoarthritis.
Well, what do we know
about bone circulation?