• Epidemiology and Risk Factors
• 41 min
  1. The changing prevalence of asthma

  • Dr. Deborah Jarvis
• 29 min
  2. Recent advances in asthma genetics

  • Prof. Miriam Moffatt
• 35 min
  3. Asthma: an epidemic caused by epigenetics?

  • Prof. David Schwartz
• 30 min
  4. Role of the microbiota in asthma

  • Prof. B. Brett Finlay
• 32 min
  5. Diet and asthma

  • Prof. Lewis Smith
• 43 min
  6. Obesity and asthma

  • Prof. Anne Dixon
• 35 min
  7. Occupational asthma: management beyond the textbooks

  • Prof. Paul Cullinan
• Clinical Phenotypes
• 42 min
  8. The origins of asthma

  • Prof. Peter Sly
• 46 min
  9. Pre-school wheeze

  • Prof. Andrew Bush
• 50 min
  10. Updates on the management of difficult asthma in school-aged children

  • Prof. Andrew Bush
• 24 min
  11. Smoking asthmatics

  • Prof. Neil Thomson
• 27 min
  12. Aspirin exacerbated respiratory disease

  • Prof. Chris Corrigan
• Mechanisms of Asthma
• 48 min
  13. Advances in asthma: airway inflammation

  • Prof. William Busse
• 48 min
  14. The role of mast cells in asthma

  • Prof. Peter Bradding
• 67 min
  15. Dendritic cells in asthma

  • Prof. Bart Lambrecht
• 30 min
  16. The airway smooth muscle in asthma

  • Prof. Judith Black
• 49 min
  17. Role of virus infection in asthma 1

  • Prof. Sebastian Johnston
• 27 min
  18. Role of virus infection in asthma 2

  • Prof. Sebastian Johnston
• 51 min
  19. Severe asthma: characterisation, mechanisms & treatment

  • Prof. Fan Chung
• 46 min
  20. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 26 min
  21. Macrophage in asthma

  • Prof. Douglas Robinson
• Diagnosis of Asthma
• 70 min
  22. Physiology of asthma and involvement of small airways

  • Prof. Charles G. Irvin
• 27 min
  23. Induced sputum in asthma

  • Prof. Antonio Spanevello
• 61 min
  24. Advances in asthma: the role of exhaled nitric oxide in the assessment and management of asthma

  • Prof. Robin Taylor
• Therapy and Management
• 41 min
  25. Pulmonary drug delivery

  • Prof. Anthony J. Hickey
• 32 min
  26. The management of chronic asthma

  • Prof. Mark Fitzgerald
• 21 min
  27. Inhaled corticosteroids and beta2-agonists

  • Dr. Omar S. Usmani
• 20 min
  28. Management of "difficult asthma"

  • Prof. Elisabeth Bel
• 47 min
  29. Management of acute exacerbations of asthma

  • Dr. Chris Fanta
• 34 min
  30. Non-pharmacological treatments for asthma

  • Prof. Neil Thomson
• 45 min
  31. Asthma: beyond the prescription

  • Prof. Martyn Partridge
• 45 min
  32. New drugs for asthma

  • Prof. Peter Barnes
• 24 min
  33. Anti-IgE therapy for asthma

  • Dr. Andrew Menzies-Gow
• Archived Lectures *These may not cover the latest advances in the field
• 45 min
  34. New drugs for asthma

  • Prof. Peter Barnes
• 35 min
  35. Asthma phenotypes in children

  • Prof. Andrew Bush
• 40 min
  36. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 42 min
  37. Severe asthma in children

  • Prof. Andrew Bush

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Agenda
3. "Severe asthma" first definition
4. "Difficult asthma" ERS taskforce definition
5. "Refractory asthma" ATS criteria
6. Revised GINA definition of severe asthma
7. Heterogeneous reasons for severe asthma
8. Reasons for asthma symptoms variety
9. "High dose" therapy
10. Definition summary
11. Treatments for severe asthma?
12. Inflammation type
13. Sinonasal polyposis
14. Effect of CRS treatment on asthma
15. Inflammation in distal airways in severe asthma
16. Extra-fine ICS effect on large and small airways
17. Extra-fine ICS effect on asthma exacerbations
18. Intense and medical resistant inflammation
19. Consistency of sputum eosinophilia over time
20. Allergic vs. intrinsic asthma
21. Mechanism of action of anti IgE
22. Effect of anti IgE on severe asthma exacerbations
23. "Intrinsic" asthma
24. Systemic steroids in 'refractory' eosinophilia
25. Anti IL-5 effect
26. Treatment with oral steroids and anti-IL-5
27. No eosinophilic inflammation
28. Clarithromycin in neutrophilic asthma
29. Macrolides in chronic stable asthma
30. Asthma and obesity
31. Asthma mechanism in obese patients
32. Weight reduction improves asthma
33. Effect of bariatric surgery on asthma severity
34. Down-titrating oral corticosteroids
35. Obese patients asthma summary
36. Eosinophilic inflammation summary
37. No eosinophilic inflammation summary
38. Implications for the future
39. "Electronic nose"
40. U-BIOPRED

Topics Covered

• Difficult asthma and severe refractory asthma
• Heterogeneous reasons for severe asthma
• "High dose" therapy
• Treatments for severe asthma
• Eosinophilic vs. non eosinophilic inflammation
• Effect of CRS treatment on asthma
• Mechanism of action of anti IgE
• Effect of anti IgE on severe asthma exacerbations
• Effect of anti IL-5 (mepolizumab) on spontaneous asthma exacerbations
• Clarithromycin in neutrophilic asthma
• Macrolides in chronic stable asthma
• Mechanisms of asthma severity in obese patients
• Implications for the future

Links

Series:

• Advances in Asthma

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011

Financial Disclosures

• Prof. Elisabeth Bel, Grant/Research Support (Principal Investigator): unrestricted grant for department from GSK (60,000 EURO), Novartis (16,000 EURO)