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- Epidemiology and Risk Factors
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41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
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29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
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35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
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30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
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32 min
5. Diet and asthma- Prof. Lewis Smith
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43 min
6. Obesity and asthma- Prof. Anne Dixon
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35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
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42 min
8. The origins of asthma- Prof. Peter Sly
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46 min
9. Pre-school wheeze- Prof. Andrew Bush
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50 min
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24 min
11. Smoking asthmatics- Prof. Neil Thomson
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27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
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48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
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48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
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67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
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30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
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49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
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27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
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51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
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46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
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70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
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27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
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61 min
- Therapy and Management
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41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
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32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
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21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
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20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
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47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
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34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
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45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
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45 min
32. New drugs for asthma- Prof. Peter Barnes
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24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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45 min
34. New drugs for asthma- Prof. Peter Barnes
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35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
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40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- Agenda
- "Severe asthma" first definition
- "Difficult asthma" ERS taskforce definition
- "Refractory asthma" ATS criteria
- Revised GINA definition of severe asthma
- Heterogeneous reasons for severe asthma
- Reasons for asthma symptoms variety
- "High dose" therapy
- Definition summary
- Treatments for severe asthma?
- Inflammation type
- Sinonasal polyposis
- Effect of CRS treatment on asthma
- Inflammation in distal airways in severe asthma
- Extra-fine ICS effect on large and small airways
- Extra-fine ICS effect on asthma exacerbations
- Intense and medical resistant inflammation
- Consistency of sputum eosinophilia over time
- Allergic vs. intrinsic asthma
- Mechanism of action of anti IgE
- Effect of anti IgE on severe asthma exacerbations
- "Intrinsic" asthma
- Systemic steroids in 'refractory' eosinophilia
- Anti IL-5 effect
- Treatment with oral steroids and anti-IL-5
- No eosinophilic inflammation
- Clarithromycin in neutrophilic asthma
- Macrolides in chronic stable asthma
- Asthma and obesity
- Asthma mechanism in obese patients
- Weight reduction improves asthma
- Effect of bariatric surgery on asthma severity
- Down-titrating oral corticosteroids
- Obese patients asthma summary
- Eosinophilic inflammation summary
- No eosinophilic inflammation summary
- Implications for the future
- "Electronic nose"
- U-BIOPRED
Topics Covered
- Difficult asthma and severe refractory asthma
- Heterogeneous reasons for severe asthma
- "High dose" therapy
- Treatments for severe asthma
- Eosinophilic vs. non eosinophilic inflammation
- Effect of CRS treatment on asthma
- Mechanism of action of anti IgE
- Effect of anti IgE on severe asthma exacerbations
- Effect of anti IL-5 (mepolizumab) on spontaneous asthma exacerbations
- Clarithromycin in neutrophilic asthma
- Macrolides in chronic stable asthma
- Mechanisms of asthma severity in obese patients
- Implications for the future
Links
Series:
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Therapeutic Areas:
Talk Citation
Bel, E. (2011, December 29). Management of "difficult asthma" [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/FVXN4274.Export Citation (RIS)
Publication History
- Published on December 29, 2011
Financial Disclosures
- Prof. Elisabeth Bel, Grant/Research Support (Principal Investigator): unrestricted grant for department from GSK (60,000 EURO), Novartis (16,000 EURO)
Management of "difficult asthma"
Published on December 29, 2011
20 min
