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- Epidemiology and Risk Factors
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41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
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29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
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35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
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30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
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32 min
5. Diet and asthma- Prof. Lewis Smith
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43 min
6. Obesity and asthma- Prof. Anne Dixon
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35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
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42 min
8. The origins of asthma- Prof. Peter Sly
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46 min
9. Pre-school wheeze- Prof. Andrew Bush
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50 min
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24 min
11. Smoking asthmatics- Prof. Neil Thomson
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27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
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48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
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48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
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67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
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30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
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49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
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27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
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51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
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46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
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70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
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27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
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61 min
- Therapy and Management
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41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
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32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
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21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
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20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
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47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
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34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
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45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
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45 min
32. New drugs for asthma- Prof. Peter Barnes
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24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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45 min
34. New drugs for asthma- Prof. Peter Barnes
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35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
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40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Asthma pathophysiology
- Clinical phenotypes of asthma
- Anti-IL5 asthma studies
- Anti-IL13 study
- Anti-TNFalpha in patients with refractory asthma
- Anti-TNF-alpha therapies
- Spectrum of steroid responsiveness
- Costs of severe asthma
- How steroids work in the airways
- Classical mechanism of glucocorticoid action
- Dexamethasone induction of MKP-1
- Molecular actions of glucocorticoids
- Dissociation of corticosteroid effects
- GR immunolocalisation in sputum cells
- Effect of FP and salmeterol on GR translocation
- Combination therapy
- Relative steroid insensitivity
- Skin blanching response to topical budesonide
- Dex fails to suppress selected gene expression
- Effect of dexamethasone on GM-CSF production
- GR beta association with steroid resistance
- MAPKs affect steroid responsiveness
- IL-2/IL-4 affect GR Kd: role of p38 MAPK
- IL-2/IL-4 induces dex-insensitivity in PBMCs
- IL-2/IL-4 modulate GR translocation ability
- Enhanced p38 MAPK activity
- New safer MAPK inhibitors with a topical steroid
- JNK activation is not repressed by prednisolone
- Steroid insensitivity induction by TCR
- Infection and steroid responsiveness
- Increased bacterial LPS expression
- Superantigen-induced GR insensitivity
- RV-induced steroid resistance in asthma
- TH-17 associated cytokines
- IL-17 attenuates steroids effects in mice
- Loss of anti-inflammatory mediators
- IL-10
- Vitamin D enhances IL-10 production
- Vitamin D therapy and IL-10 expression
- Smoking reduces steroid function in asthma
- Smoking and steroid response in asthma
- Altered glutathione homeostasis in children
- Oxidative stress prevents GR translocation
- Oxidative stress induces steroid insensitivity
- Inhibitory effect of dex and HDAC activity
- Cigarette smoke reduces HDAC activity
- HAT and HDAC activity in asthmatic biopsies
- Reduced HDAC and increased HAT activity
- Theophylline enhances dexamethasone function
- Randomisation strategy - smoking asthma
- Smoking asthma - lung function (PEF)
- Summary
- Heterogeneity of 'causes' of CS insensitivity
- Relationship between drivers of steroid resistance
- Conclusion
- Acknowledgements
Topics Covered
- Overview of asthma pathophysiology
- Patterns of severe refractory asthma
- Methods to improve steroid efficacy in severe asthma
- Mechanisms that induce steroid insensitivity; Th2 cytokines, IL-17 and infections
- Pathophysiology of severe treatment refractory asthma
- Novel anti-inflammatory approaches
- Can new combinations of drugs reverse steroid insensitivity in severe asthma?
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Adcock, I. (2011, December 29). Steroid resistance in asthma: mechanisms and potential therapies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/EHHY3796.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ian Adcock has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
