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1. Introduction
2. Role of respiratory viral infections in asthma
3. Aims
4. RSV infection and subsequent asthma and atopy
5. Risk factors in asthma development
6. Airway obstruction in RSV group
7. RVIs and risk of wheeze by age 13 (1)
8. RVIs and risk of wheeze by age 13 (2)
9. Rhinovirus wheezing LRIs are risk factors
10. RSV bronchiolitis and early life viral LRTI
11. Role of winter virus infection during infancy
12. Association between RSV infection and asthma
13. Clear genetic risk
14. Deficient Th1 response in RSV bronchiolitis
15. Impaired IFN-gamma mRNA production
16. IL-18 mRNA production by PBMCs
17. Impaired virus clearance in bronchiolitis
18. Animal models
19. Animal models of tolerance to allergen
20. Association between RVI and asthma
21. Treatment/prevention of RSV bronchiolitis
22. RSV bronchiolitis prevention prevents asthma?
23. Does RSV prophylaxis prevent? (1)
24. Does RSV prophylaxis prevent? (2)
25. Conclusions

Topics Covered

• Role of viruses in development of asthma
• Association between early life severe lower respiratory viral illness and later development of asthma
• Is this association due to a common risk factor, a causal factor, or both?
• Future studies

Links

Series:

• Advances in Asthma

Categories:

• Clinical Practice
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases
• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011
• Updated on October 13, 2014

Financial Disclosures

• Prof. Sebastian Johnston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.