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1. Introduction
2. The airway in asthma is remodelled
3. Asthmatic and non-asthmatic airways
4. Big breakthrough in 2001
5. Asthmatic and non-asthmatic cell growth
6. Asthmatic Airway Smooth Muscle (ASM) cells
7. Airway smooth muscle and ECM
8. ECM production
9. Fibronectin expression with beclomethasone
10. Wound repair
11. Wound closure in asthmatic & non-asthmatic cells
12. TGFbeta and ASM
13. CTGF induction in bronchial segments
14. Altered matrix production
15. TGFbeta induces collagen and fibronectin mRNA
16. TGFbeta influence on non-asthmatic tissue
17. Human airway smooth muscle
18. CTGF influence on non-asthmatic tissue
19. TGFbeta signalling pathways
20. TGFbeta signalling pathways- pSMAD2
21. TGFbeta signalling pathway- CTGF
22. TGFbeta signalling pathways- collagen
23. TGFbeta signalling pathways- fibronectin
24. TGFbeta signalling
25. Effect of current therapies- corticosteroids
26. Effect of current therapies- beta2 agonists
27. Roflumilast
28. Bronchial rings
29. Conclusions so far
30. Increased fibulin-1 may mediate airway remodelling
31. Fibulin-1
32. Fibulin-1 increased in vivo
33. No difference in basal fibulin 1C or 1D mRNA
34. TGFbeta induces increased fibulin-1C mRNA
35. TGFbeta induces increased fibulin-1 protein (1)
36. TGFbeta induces increased fibulin-1 protein (2)
37. TGFbeta induces increased fibulin-1 in ECM
38. Fibulin-1C antisense decreases fibulin-1 in ECM
39. Fibulin-1 in ASM involved in wound repair
40. Fibulin-1 promotes proliferation of ASM
41. Fibulin-1 does not alter migration of ASM
42. Fibulin-1 regulates airway hyper-responsiveness
43. Fibulin-1 future goals
44. Thanks

Topics Covered

• Remodelling of the asthmatic airway
• Airway smooth muscle (ASM)
• increased deposition of matrix proteins
• Asthma increases ASM
• Characteristics of ASM cells in non-asthmatics
• Characteristics of ASM in asthmatics
• ASM produces extracellular matrix (ECM) proteins
• Differences in ECM in asthmatics
• Fibulin-1 in asthma
• Fibulin as a therapeutic target

Links

Series:

• Advances in Asthma

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011

Financial Disclosures

• Prof. Judith Black has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.