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- Epidemiology and Risk Factors
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41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
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29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
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35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
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30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
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32 min
5. Diet and asthma- Prof. Lewis Smith
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43 min
6. Obesity and asthma- Prof. Anne Dixon
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35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
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42 min
8. The origins of asthma- Prof. Peter Sly
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46 min
9. Pre-school wheeze- Prof. Andrew Bush
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50 min
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24 min
11. Smoking asthmatics- Prof. Neil Thomson
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27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
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48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
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48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
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67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
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30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
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49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
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27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
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51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
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46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
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70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
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27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
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61 min
- Therapy and Management
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41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
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32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
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21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
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20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
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47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
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34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
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45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
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45 min
32. New drugs for asthma- Prof. Peter Barnes
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24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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45 min
34. New drugs for asthma- Prof. Peter Barnes
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35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
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40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- Active smoking and asthma
- Prevalence rates for active smoking in asthma
- Poor asthma control in smokers
- Chronic mucus hypersecretion in smokers
- Health care utilization in smokers with asthma
- Age-related decline in FEV1 in smokers
- Persistent airflow obstruction, smoking & asthma
- Reduced sensitivity to inhaled steroids
- Impaired response to inhaled fluticasone
- Impaired response to oral prednisolone
- Corticosteroids sensitivity
- Mechanisms of adverse effects
- Non-eosinophilic inflammatory phenotype
- Elevated induced sputum neutrophil count
- Neutrophilic inflammatory phenotype
- Increased bronchial biopsy mast numbers
- Smokers with asthma-airway inflammation
- Mechanisms for corticosteroid insensitivity
- Molecular mechanisms of steroid resistance
- Management of smoking asthmatics
- Clinical benefits of smoking cessation
- Stepwise management of chronic asthma (1)
- Change in post-BD FEV1
- Stepwise management of chronic asthma (2)
- Impaired response to inhaled beclomethasone
- Combination therapy: ICS + LABA
- Leukotriene receptor antagonist
- Tiotropium
- Potential therapies for smokers with asthma
- Restoration of corticosteroid sensitivity
- Low dose theophylline & inhaled steroid
- PPAR- gamma agonists
- PPAR-gamma agonist - rosiglitazone
- Change in FEV1 with rosiglitazone
- Potential anti-inflammatory effects of statins
- Exploratory clinical trial of atorvastatin
- Atorvastatin in smokers with asthma (1)
- Atorvastatin in smokers with asthma (2)
- Conclusions: clinical
- Conclusions: mechanisms
- Conclusions: management
- Acknowledgements
- References (1)
- References (2)
- References (3)
- References (4)
Topics Covered
- High prevalence rates of smoking in asthma
- Detrimental effects of smoking on clinical outcomes
- Impaired response to corticosteroids
- Mechanisms of adverse effects
- Management includes smoking cessation, but optimum drug therapy not established
Links
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Categories:
Therapeutic Areas:
Talk Citation
Thomson, N. (2011, December 29). Smoking asthmatics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/GOUV1183.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Neil Thomson, Grant/Research Support (Principal Investigator): Boston Scientific makes of the Alair system for bronchial thermoplasty: industry sponsored grant funding to the University of Glasgow for clinical trial work.
