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1. Introduction
2. Asthma background (1)
3. Asthma background (2)
4. Finding disease genes - candidate gene
5. Candidate gene studies
6. Finding disease genes - positional cloning
7. Positional cloned asthma genes
8. Epithelium and asthma genes
9. Over 300 sequenced genomes
10. Finding points to intervene
11. Genome wide association studies for asthma
12. GWAS - asthma
13. Childhood versus adult asthma
14. Chromosome 17q21 and EGEA
15. Global gene expression
16. GWAS: expression of immune response genes
17. ORMDL3 and affymetrix gene expression data
18. ORMDL3: possible functions?
19. Affymetrix vs. Illumina gene expression data
20. Gabriel genetics
21. QC for samples
22. PCA: population structure
23. Results from 36 studies
24. Childhood onset vs. adult onset asthma
25. Association with IgE vs. association with asthma
26. Asthma SNPs and disease risk
27. Conclusions so far
28. Function of 'new asthma genes' - IL33 and IL18
29. Function of 'new asthma genes' - SMAD3, IL2RB
30. Unattributed heritability
31. Asthma and infection
32. Microbial fauna in the body
33. 1% of bacteria may be cultured
34. Sequence detection of bacteria
35. Adults: bronchial brushings
36. Children: bronchial lavage
37. The transnational asthma genetics consortium
38. Still much to do!
39. Growing field - summary
40. Acknowledgments

Topics Covered

• Incidence of asthma
• Environment and genetic causes
• Disease identification prior to completion of sequencing of the human genome
• Genome Wide Association Study (GWAS)
• Omic technologies including global gene expression
• GABRIEL and Asthma susceptibility genes identified by GWAS
• Asthma and infection
• 16S rRNA and metagenomics
• What next

Links

Series:

• Advances in Asthma

Categories:

• Clinical Practice
• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011

Financial Disclosures

• Prof. Miriam Moffatt has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.