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- Clinical Introduction
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1. Frontotemporal dementia
- Prof. Bruce Miller
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2. Parkinson disease
- Prof. Stanley Fahn
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3. Atypical parkinsonian syndromes
- Dr. David Burn
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4. Huntington's disease
- Prof. Roger Barker
- Neuroimaging
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5. Molecular brain imaging (PET) in diseases with dementia
- Prof. Karl Herholz
- Pathology, Genetic and Molecular Aspects (1)
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6. A molecular understanding of Alzheimer's disease
- Prof. John Hardy
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7. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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9. Ubiquitination and Alzheimer related disorders
- Prof. John Mayer
- Pathology, Genetic and Molecular Aspects (2)
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10. The molecular biology of Huntington's disease
- Prof. David C. Rubinsztein
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11. Metals, oxidative stress and neurodegeneration
- Prof. Ashley Bush
- Latest Developments in the Field
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12. Animal models of tauopathy
- Prof. David Westaway
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13. Parkinson's disease and transplants
- Prof. Roger Barker
- Archived Lectures *These may not cover the latest advances in the field
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14. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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15. Motor neurone disease: molecular basis
- Prof. Kevin Talbot
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16. Alzheimer's disease (AD)
- Prof. John Hodges
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17. Frontotemporal dementia syndromes
- Prof. John Hodges
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18. Motor neurone disease: clinical aspects
- Prof. Kevin Talbot
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19. Neuro-imaging in dementia: using MRI in routine work-up
- Prof. Philip Scheltens
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20. Prion diseases
- Prof. Pierluigi Gambetti
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21. Mitochondrial disorders and neurodegeneration
- Prof. Anthony Schapira
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23. Mutations in parkinsonian syndromes
- Dr. Andrew Singleton
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25. Frontotemporal dementia
- Prof. Bruce Miller
Printable Handouts
Navigable Slide Index
- Intro slide
- Outline
- Causes of late onset dementia
- Causes of early onset dementia
- The size of the problem
- Risk factors for AD
- Familial AD (1)
- Familial AD (2)
- How common are AD gene mutations?
- What are the earliest pathological changes in AD?
- Site of hippocampus in the medial temporal lobe
- Evolution of tangles in AD
- Staging of neurofibrillary tangles in AD
- Cognitive features of AD (1)
- CANTAB PAC task
- PAL: errors at 6-pattern stage at presentation
- Autobiographical memory in AD and FTD
- Cognitive features of AD (2)
- Cognitive features of AD (3)
- Cognitive features of AD (4)
- Neuropsychiatric features of AD
- AD: Diagnostic Criteria
- Pre-dementia AD
- Criteria for MCI
- Diagnostic methods
- Cambridge MCI study
- PAL: errors at 6-pattern stage at presentation
- Conversion to AD on follow up
- PAL: outcome at 36 months at presentation
- Predictors of conversion
- Imaging
- Structural brain imaging: MRI
- 3D T1-W MRI: measurement of regions of interest
- Hippocampal volumes overlap
- Serial coregistration of MRI
- Patient with early AD: MRI - hippocampus
- 12 months later: MRI - hippocampus shrinkage
- Atrophy rates: 12 patients with AD and 14 controls
- FDG-PET + MRI coregistration
- Method
- FDG-PET finding in MCI and AD
- The posterior cingulate: BA 31/23/29/30
- Metabolic PET studies: summary
- Atypical presentations
- Potential aims of treatment
- Delay of symptomatic decline
- Drug treatments for dementia
- General principal underlying the use of AChEi
- The bottom line
- Cholinesterase inhibitors
- Management
Topics Covered
- Basic epidemiological facts on AD
- Typical and atypical symptoms
- Cognitive and physical findings
- Key clinical investigations typically undertaken
- Broad therapeutic approaches
- Natural history and prognosis
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Hodges, J. (2007, October 1). Alzheimer's disease (AD) [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/MEOP5984.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. John Hodges has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.