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Printable Handouts
Navigable Slide Index
- Introduction
- 1957: Discovery of Interferons
- Dr. Alick Issacs - 1957
- History of Interferons
- Interferon-induced biological effects
- Interferons and disease
- Interferons
- Interferons and bone marrow failure
- IFNgamma and anemia
- Jak Stat pathways
- Type I IFN-dependent gene transcription
- Other signaling cascades
- P38 map kinase family
- P38 in interferon signaling (1)
- P38 in interferon signaling (2)
- Interferons and hematopoiesis
- p38 and hematopoiesis
- p38 and MapKapK-2 in CFU-E progenitors
- Functional relevance of the pathway
- Pharmacological inhibition of p38 and IFNalpha
- Pharmacological inhibition of MEK ERK
- Pharmacological inhibition of p38 and IFNbeta
- Myelosuppressive cytokines
- TGFbeta dependent activation of p38
- Inhibition of p38 and TGFbeta
- IFNgamma and TNFalpha in normal bone marrow
- SB203580
- Aplastic anemia and p38 MAPK inhibition
- P38 map kinases
- P38alpha expression in knockout cells
- IFNalpha dependent gene transcription
- IFNbeta and IFNgamma gene transcription
- ISGF3 and SIF complexes
- P38alpha and Stat1 binding to ISRE
- ISGs and IFN biological responses
- mTOR
- mRNA translation of IFN-responsive genes
- Upstream effectors of the mTOR pathway
- Phosphorylation/activation of Akt
- Type I IFN-dependent activation of S6K pathway
- Type I IFN-dependent phosphorylation of 4E-BP1
- Upregulation of ISG15 and IP10 is Akt-dependent
- Defective Isg15 mRNA translation
- Defective antiviral responses in Akt1/2 -/-MEFs
- Pathway map (1)
- IFN-induced activation of Akt is PI3K-dependent
- Defective phosphorylation of 4E-BP1
- IFN-dependent upregulation of ISG15
- Cells lacking p85alpha/p85beta
- p85alpha/p85beta knockout MEFs
- Defective antiviral responses in p85a/b -/- MEFs
- Pathway map (2)
- Mnk kinases
- IFN-dependent phosphorylation of Mnk1 and eIF4E
- IFN-inducible eIF4E phosphorylation
- IFN-dependent Mnk activation
- IFN-inducible Mnk and eIF4E phosphorylation
- Isg15 protein expression if Mnk-kinase dependent
- Stat 1 phosphorylation and Isg15 transcription
- mRNA translation of Isg15 and Isg54
- The Mnk eIF4E pathway (1)
- The Mnk eIF4E pathway (2)
- IFN-dependent suppression of hematopoiesis (1)
- IFN-dependent suppression of hematopoiesis (2)
- Summary
Topics Covered
- Mechanisms of action of interferons
- Interferon receptors
- Interferon activated signaling pathways
- Jak-Stat pathways
- Map kinase pathways
- Akt/mTOR pathway
- Interferons and hematopoiesis
- Interferons and bone marrow failure
Links
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Talk Citation
Platanias, L. (2011, December 5). Signaling for the interferon family of receptors and ligands and clinical implications [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 12, 2024, from https://doi.org/10.69645/RXKT5627.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Leonidas Platanias has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Signaling for the interferon family of receptors and ligands and clinical implications
Published on December 5, 2011
58 min
A selection of talks on Haematology
Transcript
Please wait while the transcript is being prepared...
0:00
This is Leon Platanias from Northwestern University in Chicago,
and today I will discuss the signaling pathways by
which the interferon family of receptors and ligands work.
I will review work going back many years and
come up to more recent and up-to-date information,
and I will try to cover up both mechanisms that
regulate transcriptional activation in the interferon system,
as well as MRNA translation of interferon-stimulated genes.
0:36
The interferons were discovered initially in 1957,
and that was work that was performed by primarily two researchers.
One was Alick Isaacs and the other one was Jean Lindenmann,
and they were able to provide evidence at that point
for the existence of a substance -
At that time interferon was thought to be only one -
The evidence that they provided was that there is a substance, a cytokine,
although it was not called cytokine in those days,
that inhibits viral replication;
and that was a very important discovery at the time.
1:23
Those days, they didn't have very modern equipment,
and taking into account the difficulties that they had to do the research,
the equipment they had,
and the technology that they had at that time,
that was a remarkable discovery.
In this slide we see the history of interferons.
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