• View the Talks
• 52 min
  1. Principles of cytokine-receptor interactions and signal transduction

  • Dr. Xiaoxia Li
• 47 min
  2. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 74 min
  3. Cytokines and CD4 T Cells: dance partners at the immunology ball

  • Dr. William E. Paul
• 38 min
  4. The gamma c family of cytokines

  • Dr. Warren J. Leonard
• 29 min
  5. Interleukin-6: back to the future

  • Prof. Tadamitsu Kishimoto
• 59 min
  6. Regulation of the immune response to pathogens 1

  • Prof. Anne O’Garra
• 33 min
  7. Regulation of the immune response to pathogens 2

  • Prof. Anne O’Garra
• 23 min
  8. IL-17 cytokine family and receptors

  • Prof. Chen Dong
  • Dr. Seon Hee Chang
• 40 min
  9. The b common (bc) family of cytokines, receptors and ligands

  • Prof. Angel Lopez
  • Dr. Timothy Hercus
• 29 min
  10. TNF superfamily cytokines and receptors in the healthy and diseased immune system

  • Dr. Richard Siegel
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 49 min
  12. IL-1 as a key inflammatory regulator in autoinflammatory diseases

  • Dr. Raphaela Goldbach-Mansky
• 58 min
  13. Signaling for the interferon family of receptors and ligands and clinical implications

  • Prof. Leonidas Platanias
• 45 min
  14. Interferons as antivirals: translating basic research into clinical application

  • Prof. Eleanor N. Fish
• 49 min
  15. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 22 min
  16. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  17. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 49 min
  18. Receptor identification for alarmins and DAMPs

  • Dr. Joost J. Oppenheim
• 41 min
  19. Assays for cytokines and cytokine assay performance 1

  • Prof. Theresa Whiteside
• 39 min
  20. Assays for cytokines and cytokine assay performance 2

  • Prof. Theresa Whiteside
• 23 min
  21. Interleukin-7 and T cells

  • Dr. Scott Durum
• Archived Lectures *These may not cover the latest advances in the field
• 32 min
  22. Assays for cytokines and cytokine assay standardization

  • Prof. Theresa Whiteside

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Objectives
3. What monogenic autoinflammatory diseases are
4. Presentation of autoinflammatory diseases
5. Definition of inflammation
6. Immune dysregulatory conditions
7. Autoinflammatory diseases
8. Monogenic autoinflammatory diseases
9. Genetic cause for autoinflammatory diseases
10. IL-1 mediated autoinflammatory diseases
11. FCAS and MWS
12. NOMID/CINCA
13. The disease spectrum of CAPS
14. Prognosis in CAPS
15. Epidemiology
16. Differential diagnosis and diagnostic clues
17. Mutations identified in CIAS1/NLRP3
18. Pathogenesis
19. The inflammasome
20. Is NOMID an IL-1 disease?
21. Blocking IL-1 in NOMID with Anakinra
22. CNS disease
23. Controlling CNS inflammation
24. Inner ear
25. Eye
26. Musculoskeletal manifestations
27. No response to IL-1 blocking therapy
28. Pathogenesis of bone lesions in NOMID
29. Caspase-1 and PGE inhibition
30. Lessons from clinical studies
31. CAPS/NOMID summary
32. Approved treatments: Rilonacept in CAPS
33. Canakinumab/Ilaris in CAPS
34. Currently approved IL-1 inhibitors
35. Deficiency of the IL-1 receptor antagonist
36. Case report: 7 month old boy from Canada
37. Response to IL-1 blocking therapy
38. Genetic workup using a candidate gene approach
39. Genomic deletion in a Puerto Rican patient
40. Founder mutations in DIRA
41. Laboratory response to treatment with Anakinra
42. Vertebral manifestations: radiography
43. DIRA summary
44. Mice have different disease manifestations
45. Comparison NOMID-DIRA (1)
46. Comparison NOMID-DIRA (2)
47. IL-1 expression in the skin
48. Localization of neutrophilic infiltrate
49. Does IL-1 play a role in polygenic diseases?
50. Evidence of IL-1 in the pathogenesis of SOJIA
51. SOJIA - a polygenic IL-1 disease?
52. Inflammasome is activated by danger signals
53. "Metabolic" autoinflammatory diseases?
54. Gout, a "metabolic" autoinflammatory disease?
55. Type 2 diabetes, an autoinflammatory disease?
56. Or a "metabolic" autoinflammatory disease?
57. Inflammasome activation in obesity
58. IL-1 blockade improves glucose tolerance
59. Organ specificity is multi-factorial
60. Summary
61. Acknowledgements
62. The NIH

Topics Covered

• Understand the concept of autoinflammatory syndromes and typical clinical features
• Understand the role of IL-1 on the phenotype of two IL-1 mediated autoinflammatory syndromes: NOMID and DIRA
• Understand the impact of the discovery of the role of IL-1 in rare diseases
• The understanding of the pathogenesis of common diseases such as gout and Type II diabetes

Links

Series:

• Cytokines

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on December 5, 2011

Financial Disclosures

• Dr. Raphaela Goldbach-Mansky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.