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2. Toll-like receptor signalling during infection and inflammation
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3. Cytokines and CD4 T Cells: dance partners at the immunology ball
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4. The gamma c family of cytokines
- Dr. Warren J. Leonard
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5. Interleukin-6: back to the future
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6. Regulation of the immune response to pathogens 1
- Prof. Anne O’Garra
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7. Regulation of the immune response to pathogens 2
- Prof. Anne O’Garra
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8. IL-17 cytokine family and receptors
- Prof. Chen Dong
- Dr. Seon Hee Chang
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9. The b common (bc) family of cytokines, receptors and ligands
- Prof. Angel Lopez
- Dr. Timothy Hercus
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12. IL-1 as a key inflammatory regulator in autoinflammatory diseases
- Dr. Raphaela Goldbach-Mansky
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13. Signaling for the interferon family of receptors and ligands and clinical implications
- Prof. Leonidas Platanias
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14. Interferons as antivirals: translating basic research into clinical application
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15. Chemokines and their receptors: their biology and therapeutic relevance
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16. Humoral innate immunity and the acute phase response 1
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17. Humoral innate immunity and the acute phase response 2
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18. Receptor identification for alarmins and DAMPs
- Dr. Joost J. Oppenheim
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19. Assays for cytokines and cytokine assay performance 1
- Prof. Theresa Whiteside
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20. Assays for cytokines and cytokine assay performance 2
- Prof. Theresa Whiteside
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21. Interleukin-7 and T cells
- Dr. Scott Durum
- Archived Lectures *These may not cover the latest advances in the field
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22. Assays for cytokines and cytokine assay standardization
- Prof. Theresa Whiteside
Printable Handouts
Navigable Slide Index
- Introduction
- Objectives
- What monogenic autoinflammatory diseases are
- Presentation of autoinflammatory diseases
- Definition of inflammation
- Immune dysregulatory conditions
- Autoinflammatory diseases
- Monogenic autoinflammatory diseases
- Genetic cause for autoinflammatory diseases
- IL-1 mediated autoinflammatory diseases
- FCAS and MWS
- NOMID/CINCA
- The disease spectrum of CAPS
- Prognosis in CAPS
- Epidemiology
- Differential diagnosis and diagnostic clues
- Mutations identified in CIAS1/NLRP3
- Pathogenesis
- The inflammasome
- Is NOMID an IL-1 disease?
- Blocking IL-1 in NOMID with Anakinra
- CNS disease
- Controlling CNS inflammation
- Inner ear
- Eye
- Musculoskeletal manifestations
- No response to IL-1 blocking therapy
- Pathogenesis of bone lesions in NOMID
- Caspase-1 and PGE inhibition
- Lessons from clinical studies
- CAPS/NOMID summary
- Approved treatments: Rilonacept in CAPS
- Canakinumab/Ilaris in CAPS
- Currently approved IL-1 inhibitors
- Deficiency of the IL-1 receptor antagonist
- Case report: 7 month old boy from Canada
- Response to IL-1 blocking therapy
- Genetic workup using a candidate gene approach
- Genomic deletion in a Puerto Rican patient
- Founder mutations in DIRA
- Laboratory response to treatment with Anakinra
- Vertebral manifestations: radiography
- DIRA summary
- Mice have different disease manifestations
- Comparison NOMID-DIRA (1)
- Comparison NOMID-DIRA (2)
- IL-1 expression in the skin
- Localization of neutrophilic infiltrate
- Does IL-1 play a role in polygenic diseases?
- Evidence of IL-1 in the pathogenesis of SOJIA
- SOJIA - a polygenic IL-1 disease?
- Inflammasome is activated by danger signals
- "Metabolic" autoinflammatory diseases?
- Gout, a "metabolic" autoinflammatory disease?
- Type 2 diabetes, an autoinflammatory disease?
- Or a "metabolic" autoinflammatory disease?
- Inflammasome activation in obesity
- IL-1 blockade improves glucose tolerance
- Organ specificity is multi-factorial
- Summary
- Acknowledgements
- The NIH
Topics Covered
- Understand the concept of autoinflammatory syndromes and typical clinical features
- Understand the role of IL-1 on the phenotype of two IL-1 mediated autoinflammatory syndromes: NOMID and DIRA
- Understand the impact of the discovery of the role of IL-1 in rare diseases
- The understanding of the pathogenesis of common diseases such as gout and Type II diabetes
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Talk Citation
Goldbach-Mansky, R. (2011, December 5). IL-1 as a key inflammatory regulator in autoinflammatory diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/TUIB3649.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Raphaela Goldbach-Mansky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
IL-1 as a key inflammatory regulator in autoinflammatory diseases
Published on December 5, 2011
49 min