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  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

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Navigable Slide Index

1. Introduction
2. Talk outline
3. IL-1 has many names
4. IL-1 is a pleiotropic cytokine
5. IL-1 biology
6. IL-1 effects on non-hematopoietic tissues
7. IL-1 effects on the innate immune system
8. IL-1 effects on the adaptive immune system
9. IL-1 molecules & receptors
10. IL-1alpha and IL-1beta
11. IL-1 receptor type 1
12. IL-1 binds to the type 1 IL-1 receptor
13. The IL-1 receptor is a heterodimer
14. The IL-1 family
15. IL-1Ra does not signal
16. Type 2 IL-1 receptor is a decoy receptor
17. Type 2 IL-1R decoys IL-1 but not IL-1Ra
18. IL-1 secretion, signaling, and regulation
19. IL-1 processing and secretion
20. IL-1 signaling
21. IL-1 regulation
22. IL-1 and disease
23. IL-1 mediated diseases (1)
24. IL-1 mediated diseases (2)
25. IL-1 disease association (1)
26. IL-1 disease association (2)
27. IL-1 inhibitors
28. Other IL-1 family members
29. IL-1 family members (as of 2011)
30. IL-1 family tree
31. IL-3 three dimensional structures
32. IL-1 locus
33. IL-1 receptor family (1)
34. IL-1 receptor family (2)
35. IL-18bp regulates IL-18 signaling
36. Soluble receptors regulate IL-33
37. IL-36Ra antagonizes IL-36 signaling
38. SIGIRR regulates all of IL-1, IL-18, IL-33 and IL-36
39. IL-1 family members in T cell polarization
40. IL-18 biology and disease association
41. IL-18 biology
42. IL-18 disease association
43. IL-33
44. IL-33 biology
45. Association of IL-33 and asthma (1)
46. IL-33 affects IL-33R in asthma-associated cells
47. Association of IL-33 and asthma (2)
48. IL-33 drives asthma by several mechanisms
49. IL-36 and psoriasis
50. IL-36 tissue expression pattern
51. IL-36 cytokines are processed
52. IL-36 truncation enhances their activity
53. IL-36 is over-expressed in psoriatic skin
54. IL-36alpha over-expression in mice (1)
55. IL-36alpha over-expression in mice (2)
56. IL-36 cytokines play a role in psoriasis
57. Inhibition of IL-36 ameliorates human psoriasis
58. IL-37
59. Conclusions
60. Additional reading

Topics Covered

• Introduction to IL-1 and its biology
• Molecular characterization of IL-1 and its receptor
• IL-1 secretion, signaling and regulation
• IL-1 disease association
• Other members of the IL-1 family, including structure, expression, receptors, regulation
• IL-18
• IL-33 and asthma
• IL-36 and psoriasis

Links

Series:

• Cells of the Innate Immune System
• Cytokines

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on December 5, 2011

Financial Disclosures

• Dr. John Sims, Other: owns stock and stock options in Amgen; was an Amgen employee until 1 Jan 2012.