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2. Toll-like receptor signalling during infection and inflammation
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4. The gamma c family of cytokines
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5. Interleukin-6: back to the future
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6. Regulation of the immune response to pathogens 1
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7. Regulation of the immune response to pathogens 2
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8. IL-17 cytokine family and receptors
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12. IL-1 as a key inflammatory regulator in autoinflammatory diseases
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17. Humoral innate immunity and the acute phase response 2
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18. Receptor identification for alarmins and DAMPs
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20. Assays for cytokines and cytokine assay performance 2
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21. Interleukin-7 and T cells
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- Archived Lectures *These may not cover the latest advances in the field
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22. Assays for cytokines and cytokine assay standardization
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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- IL-1 has many names
- IL-1 is a pleiotropic cytokine
- IL-1 biology
- IL-1 effects on non-hematopoietic tissues
- IL-1 effects on the innate immune system
- IL-1 effects on the adaptive immune system
- IL-1 molecules & receptors
- IL-1alpha and IL-1beta
- IL-1 receptor type 1
- IL-1 binds to the type 1 IL-1 receptor
- The IL-1 receptor is a heterodimer
- The IL-1 family
- IL-1Ra does not signal
- Type 2 IL-1 receptor is a decoy receptor
- Type 2 IL-1R decoys IL-1 but not IL-1Ra
- IL-1 secretion, signaling, and regulation
- IL-1 processing and secretion
- IL-1 signaling
- IL-1 regulation
- IL-1 and disease
- IL-1 mediated diseases (1)
- IL-1 mediated diseases (2)
- IL-1 disease association (1)
- IL-1 disease association (2)
- IL-1 inhibitors
- Other IL-1 family members
- IL-1 family members (as of 2011)
- IL-1 family tree
- IL-3 three dimensional structures
- IL-1 locus
- IL-1 receptor family (1)
- IL-1 receptor family (2)
- IL-18bp regulates IL-18 signaling
- Soluble receptors regulate IL-33
- IL-36Ra antagonizes IL-36 signaling
- SIGIRR regulates all of IL-1, IL-18, IL-33 and IL-36
- IL-1 family members in T cell polarization
- IL-18 biology and disease association
- IL-18 biology
- IL-18 disease association
- IL-33
- IL-33 biology
- Association of IL-33 and asthma (1)
- IL-33 affects IL-33R in asthma-associated cells
- Association of IL-33 and asthma (2)
- IL-33 drives asthma by several mechanisms
- IL-36 and psoriasis
- IL-36 tissue expression pattern
- IL-36 cytokines are processed
- IL-36 truncation enhances their activity
- IL-36 is over-expressed in psoriatic skin
- IL-36alpha over-expression in mice (1)
- IL-36alpha over-expression in mice (2)
- IL-36 cytokines play a role in psoriasis
- Inhibition of IL-36 ameliorates human psoriasis
- IL-37
- Conclusions
- Additional reading
Topics Covered
- Introduction to IL-1 and its biology
- Molecular characterization of IL-1 and its receptor
- IL-1 secretion, signaling and regulation
- IL-1 disease association
- Other members of the IL-1 family, including structure, expression, receptors, regulation
- IL-18
- IL-33 and asthma
- IL-36 and psoriasis
Links
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Talk Citation
Sims, J. (2011, December 5). An introduction to the interleukin-1 family of cytokines [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/KLBG4190.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. John Sims, Other: owns stock and stock options in Amgen; was an Amgen employee until 1 Jan 2012.