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1. Introduction
2. The TNF-TNFR superfamily: history
3. Genomics of the TNF/TNFR superfamily
4. The TNF/TNFR superfamily: overview
5. The TNF/TNFR superfamily: main areas of action
6. TNF-receptor superfamily signaling types
7. TNF-SF structure-function: TNF ligands
8. TNF receptors: extracellular domains
9. Ligand:Receptor binding
10. TNF-SF structure-function: Death domain
11. TNF-SF structure-function: TRAF domain
12. Fas and TNFR family members pre-association
13. Use of the PLAD by other non-classical ligands
14. Apoptosis triggered through DISC recruitment
15. FAS-FADD crystal structure
16. Fas engagement induces receptor clustering
17. Gene expression through TRAF proteins
18. Dual signaling by TNF receptors
19. Regulation by dynamic expression of ligands
20. TNF-SF functions: lymph node development
21. TNF-SF functions: innate immunity enhancement
22. TNF-SF functions: B cell co-stimulation
23. TNF-SF functions: T-cell co-stimulation
24. TNFR in T cell expansion and contraction
25. TL1A-DR3 interactions critical for effector T cells
26. Negative regulation through apoptosis induction
27. Multiple pathways lead to programmed cell death
28. TNF-SF functions: osteoclast development
29. Molecular mechanisms of genetic diseases
30. ALPS - genetic defects in the Fas pathway
31. Fas death domain mutants
32. Extracellular Fas mutations
33. Therapeutic uses of TNF-SF blockade
34. Other anti-inflammatory agents against TNF-SF
35. Review papers for further reading

Topics Covered

• Genomics of the TNF/TNFR superfamily
• TNF/TNFR signaling types
• Various domains of TNFR
• TNF ligands and receptor binding
• Fas and the TNFR family
• Apoptosis through DISC recruitment
• FAS-FADD crystal structure
• Gene expression through TRAF proteins and regulation by dynamic expression of ligands
• Lymph node development
• Innate immunity enhancement
• B & T cells and the TNFR superfamily
• Multiple programmed cell death pathways
• Osteoclast development
• Molecular mechanisms of genetic diseases and defects in the Fas pathway
• Fas intra and extracellular mutations
• Therapeutics and anti-inflammatory uses of TNF superfamily blockade

Links

Series:

• Cytokines

Categories:

• Cancer
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Siegel, R. (2011, December 5). TNF superfamily cytokines and receptors in the healthy and diseased immune system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 16, 2025, from https://doi.org/10.69645/GCWU9374.
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Publication History

• Published on December 5, 2011

Financial Disclosures

• Dr. Richard Siegel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.