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1. Introduction
2. What is the gut-brain axis?
3. The intestinal microbiota
4. Why study intestinal bacteria & the brain?
5. C. jejuni alters brain activity and behaviour
6. C. rodentium induces anxiety like behaviour
7. Brain function in germ free mice
8. Germ free mice exhibit increase in ACTH levels
9. Germ-free mice exhibit less anxiety
10. Microbiota manipulation by dietary modification
11. Microbiota alternations: memory and learning
12. Manipulation of microbiota with antimicrobials
13. Perturbation of the microbiota by antimicrobials
14. Antimicrobials effect on bacterial composition
15. Behavioural testing in mice
16. Antimicrobials increase exploratory behaviour
17. Malaise effect and antimicrobial (ATM) treatment
18. Alterations in behaviour and changes in BDNF
19. Investigation of underlying mechanisms
20. ATM treatment and inflammatory activity
21. ATM treatment and serum cytokine levels
22. ATM induced changes and vagal integrity
23. Behavioural phenotype transfer via microbiota
24. Behaviour & microbiota differences among mice
25. NIH Swiss & Balb/c mice behavioural differences
26. NIH Swiss & Balb/c mice microbiota differences
27. Experimental strategy
28. Germ free NIH Swiss colonized with Balb/c flora
29. Colonization of Balb/c mice with NIH Swiss flora
30. Changes in NIH Swiss colonized with Balb/c flora
31. Summary
32. Microbiota-to-brain communication
33. Candidate mediators
34. The intestinal microbiota influences brain
35. Does the brain influence the microbiota?
36. Stress and the intestinal microbiota
37. Maternal separation disrupts microflora integrity
38. Stress-induced alterations in microbiota
39. The brain influences microbial composition in gut
40. Bi-directional intestinal microbiota-gut-brain axis
41. Clinical implications
42. Acknowledgements
43. References

Topics Covered

• The interaction between the intestinal microbiota and the brain
• The microbiota as a component input determining behaviour
• The common occurrence of psychiatric co-morbidity with functional and inflammatory gastrointestinal diseases

Links

Series:

• Microbiota

Categories:

• Microbiology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on September 27, 2011

Financial Disclosures

• Prof. Stephen Collins has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.