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1. Introduction
2. Interaction of microbes with the immune system
3. T helper cell differentiation
4. Effects of IL-17, IL-17F and IL-22
5. Balance of inflammatory and regulatory T cells
6. Inflammatory lymphoid cells in the lamina propria
7. Nuclear receptor ROR-gamma-t
8. Nuclear receptors family
9. Products of the Rorc locus
10. Functions of ROR-gamma-t in the immune system
11. Cryptopatch in the small intestine
12. Loss of IL-17 producing cells
13. ROR-gamma-t and Th17 cells
14. Plasticity of Th17:Treg differentiation
15. TGF-beta concentration governs Th17:Treg choice
16. Co-expression of Foxp3 and ROR-gamma-t
17. Reciprocal relationship of ROR-gamma-t and Foxp3
18. Transfer colitis model
19. ROR-gamma-deficient CD4+ T cells and colitis
20. Histopathology in the transfer colitis model
21. Distribution of IL-17 producing cells in the periphery
22. Commensal bacteria and T cells intestinal balance
23. Antibiotics reduce Th17 cell differentiation
24. Th17 cells fail to develop in germ-free mice
25. Colony specific influence on Th17 differentiation
26. Phylochip analysis of microbiota
27. Commensal microbiota in C57BL/6 mice
28. Segmented filamentous bacteria
29. Terminal ileum of Jax and Tac mice
30. SFB in the terminal ileum of Taconic B6 mice
31. SFB interaction with intestine epithelia
32. SFB induce Th17 cells in the small intestine (SI)
33. SFB-induced gene expression changes in the SI
34. Serum Amyloid A isoforms are induced by SFB
35. Does colonization with SFB provide protection?
36. Role of balanced microbiota in intestinal health
37. Reduced Citrobacter titers in SFB colonized mice
38. SFB colonization protects host from colitis
39. Th17-mediated autoimmune disease
40. Spontaneous arthritis in K/BxN mouse model
41. Microbiota, Th17 cells and mucosal protection
42. Communication of microbiota and host cells
43. SFB induction of Th17 cells
44. Transcription factors in Th17 cell differentiation
45. Transcriptional networks
46. Acknowledgements (1)
47. Acknowledgements (2)

Topics Covered

• Interaction of the microbiomes with the immune system
• T helper cell differentiation in response to innate immune system cytokines
• Effects of IL-17, IL-17F and IL-22
• Balance of inflammatory and regulatory T cells in the intestine
• Retinoic Acid Receptor (RAR)
• Related Orphan Nuclear Receptor
• Transfer colitis model
• Commensal bacteria and T cell balance in the intestine
• Lamina propria
• Segmented filamentous bacteria
• Does colonization with SFB provide protection from pathogenic microbes?
• Does colonization with SFB influence TH17-mediated autoimmune disease?
• SFB induction of TH17 cells

Links

Series:

• Microbiota

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Littman, D. (2011, September 27). The role of the enteric microbiota in T cell differentiation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/2101/.
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Publication History

• Published on September 27, 2011

Financial Disclosures

• Prof. Dan Littman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.