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1. Introduction
2. Obesity trends in US adults, 1989-2010
3. Obesity trends in U.S. children
4. The human microbiome
5. Major bacterial phyla at diverse anatomical sites
6. Questions related to the human microbiome (1)
7. Colonizing microbe-host interactions
8. Helicobacter pylori
9. Geographic structure of H. pylori populations
10. H. pylori interacting with epithelial cell
11. CagA translocation and phosphorylation
12. Studying H. pylori-epithelial cell interactions
13. Increasing S-phase proportion in AGS cells
14. H. pylori genotype effects on cyclinD1
15. Intra-host CagA diversity
16. Regulation of H. pylori-induced MMP-1 secretion
17. CagA and JAK/STAT, SHP2/ERK pathways
18. Who we are
19. H. pylori prevalence in the United States
20. The "disappearing microbiota" hypothesis
21. Maternal effects on next generation microbiota
22. Changes in human ecology affecting microbiota
23. Hygiene vs. disappearing microbiota hypotheses
24. Effects of H. pylori loss on gastric microbiome
25. Microbiota-gastrointestinal mucosa interactions
26. T-helper responses in Hp positive vs. negative
27. Hp effects on IL-10, foxP3, TGF-b1 mRNA levels
28. Leptin and leptin receptor in gastric tissues
29. Gastric fundus Ghrelin- immunochemical detection
30. Hp effects on pre and post-meal Ghrelin
31. Hp presence affects gastric physiology
32. Cows on a farm
33. Use of antibiotics on the farm
34. Sub-therapeutic antibiotic treatment
35. Questions related to the human microbiome (2)
36. Mouse vs. human development timeline
37. C57Bl/6 mice used in STAT and PAT studies
38. Adiposity in STAT and control mice at 10 weeks
39. Abdominal fat distribution
40. Short chain fatty acid production
41. Liver adiposity in control and STAT mice
42. Steps in hepatic microarray analysis
43. Antibiotic use in U.S children
44. STAT experimental design
45. PAT experimental design
46. PAT hypothesis
47. PAT study design
48. A model of early life development
49. Acknowledgement
50. H. pylori collaborators
51. STAT/PAT research team

Topics Covered

• The microbiome is ancient and performs important physiologic functions in humans
• The microbiome has been changing in recent years with consequences for both health and disease
• The changing ecology of the stomach with relation to Helicobacter pylori provides one example of changed physiology, and disease risk
• Animal models with early life exposure to antibiotics provide a second example of altered metabolism

Links

Series:

• Microbiota

Categories:

• Microbiology

Talk Citation

Blaser, M. (2011, September 27). Disappearing microbiota and human metabolic health [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/JCQH4943.
Export Citation (RIS)

Publication History

• Published on September 27, 2011

Financial Disclosures

• Prof. Martin Blaser has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.