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1. Introduction
2. Talk outline (1)
3. The second human genome project
4. Bacterial pathogens/toxins - CDC
5. Intestine: 8 divisions, 800 species, 7000 strains
6. The microbiota are critical to the host animal
7. Conceptual impediments
8. Technical impediments
9. Vistas opened by developed biotechnology
10. The integration of microbiology and host biology
11. Calendar of earth history
12. The last week
13. Appearance of somatic recombination
14. Differences in immunity-vertebrates v. invertebrates
15. Talk outline - using animal models
16. The evolutionary trajectory to humans
17. Origin of human genes associated with disease (1)
18. Basic principles of animal-bacterial interactions
19. Origin of human genes associated with disease (2)
20. Insights into human biology
21. Nobel prize awards in developmental biology
22. Questions where models may provide insight
23. The squid-vibrio light organ symbiosis
24. Chronic colonization of animal epithelia
25. Topics studied using squid-vibrio symbiosis
26. The bacterial signals (MAMPs)
27. The landscape
28. Mucus shedding induced by the peptidoglycan
29. Symbionts dominate in the aggregates
30. The juvenile light organ
31. Colonization of the host's epithelium-lined crypts
32. The "Winnowing"
33. Colonization of host tissues
34. Symbiont-induced remodeling of host light organ
35. MAMPs direct morphogenesis
36. Symbiont induction of host tissue development
37. Daily rhythms of symbiont associated tissues (1)
38. Genes regulation in host and symbionts
39. Future studies
40. Daily rhythms of symbiont associated tissues (2)
41. Conclusions
42. Acknowledgements

Topics Covered

• Human organ systems interacting with bacteria
• Intestine: 8 divisions, 800 species, 7000 strains
• How critical are the microbiota to the overall biology of the host animal?
• Conceptual and technical impediments
• Impact on the immune system
• Genes associated with human genetic disease
• The squid-vibrio light organ symbiosis
• Microbe Associated Molecular Patterns
• Colonization of host tissues and development of the symbiosis
• Symbiont induction of host tissue development
• Daily rhythms of symbiont associated tissues

Links

Series:

• Microbiota

Categories:

• Microbiology

Talk Citation

McFall-Ngai, M. (2011, September 27). A new frontier in biology: deciphering the molecular language of symbiosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/AOUO3431.
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Publication History

• Published on September 27, 2011
• Archived on June 22, 2016

Financial Disclosures

• Prof. Margaret McFall-Ngai has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.