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1. Introduction
2. Herpes simplex virus type-1 & type-2
3. Labial herpes-cold sores
4. Common diseases caused by HSV
5. HSV infections are life-long
6. All viruses are obligate intracellular parasites
7. HSV-the first virus treated effectively with antivirals
8. Animal models of HSV showed antivirals effectivity
9. Findings for antiviral compounds
10. Anticipated problems: latency and drug-resistance
11. Productive replication cycle of herpes virus
12. Inhibitors are compared by measuring their EC50
13. Plaque-reduction assay for HSV-1 inhibitor
14. Plaque reduction assay in tissue culture
15. Virus sensitivity to two antiviral compounds
16. Nucleoside analogues: successful HSV inhibitors
17. Natural nucleosides
18. Idoxuridine: first antiviral nucleoside analogue
19. Nucleoside analogues disrupt HSV DNA synthesis
20. Selective inhibition of HSV
21. Herpes simplex virus thymidine kinase - HSV TK
22. HSV TK phosphorylates the nucleoside analogue
23. Further antiviral pyrimidine nucleoside analogues
24. Adenine arabinoside
25. A problem with "first generation" analogues
26. Purine nucleoside analogues
27. Normal conversion of deoxyguanosine
28. Acyclovir conversion to acyclovir triphosphate
29. ACV-TP binds to HSV DNA-pol in place of dGTP
30. Acyclovir: anti HSV-1 activity in clinical isolates
31. Achieving in vivo inhibitory concentrations
32. Acyclovir & penciclovir have similar activity
33. ACV and PCV: low aqueous solubility
34. The solution to the oral bioavailability problem
35. Prudrugs conversion yields active compounds
36. Serum levels of acyclovir following valaciclovir
37. Similar prodrug strategy for ganciclovir
38. HSV infections in immunocompromised host
39. Remaining problems in HSV disease management
40. History of herpes simplex virus antiviral drugs

Topics Covered

• Herpes simplex virus type-1 & type-2
• Common diseases caused by HSV
• HSV infections are life-long
• All viruses are obligate intracellular parasites
• HSV-the first virus treated effectively with antivirals
• Findings for antiviral compounds
• Nucleoside analogues: successful HSV inhibitors
• Acyclovir & penciclovir have similar activity, low aqueous solubility
• Prudrugs conversion yields active compounds
• Remaining problems in HSV disease management

Links

Series:

• Antivirals

Categories:

• Clinical Practice
• Microbiology
• Pharmaceutical Sciences

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on August 30, 2011

Financial Disclosures

• Dr. Hugh J. Field has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.