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- Principles in Bacterial Pathogenesis
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43 min
1. The molecular basis of bacterial pathogenicity: an overview- Prof. B. Brett Finlay
- Gram Negative Pathogens
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50 min
2. Deciphering shigella invasion of epithelial cells- Prof. Philippe Sansonetti
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43 min
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57 min
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34 min
5. Bordetella pertussis- Prof. Alison Weiss
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37 min
6. Salmonellae: molecular basis of infection- Prof. Samuel Miller
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43 min
7. The diversity of Escherichia coli infections- Prof. Michael Donnenberg
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18 min
8. Bacterial activation of epithelial signaling- Prof. Alice Prince
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48 min
9. Human pathogenic Yersinia species- Prof. James Bliska
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32 min
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46 min
11. Dental pathogens- Prof. Ann Progulske-Fox
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35 min
12. Haemophilus- Prof. Robert Munson
- Gram Positive Pathogens
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53 min
13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model- Prof. Pascale Cossart
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42 min
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48 min
15. Molecular pathogenesis and prevention of Staphylococcus aureus infections- Prof. Olaf Schneewind
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49 min
16. Streptococcus pyogenes disease and molecular pathogenesis- Prof. P. Patrick Cleary
- Host Responses
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29 min
17. Microbial recognition and the immune response- Dr. Dana Philpott
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40 min
18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions- Prof. Vanessa Sperandio
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47 min
19. Toll-like receptor signalling during infection and inflammation- Prof. Luke O'Neill
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56 min
20. The human indigenous microbiota- Prof. David Relman
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53 min
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47 min
22. Role of neutrophils in acute lung injury and repair- Prof. Gregory Downey
- Preventatives and Therapeutics
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35 min
23. Antibiotics and antibiotic resistance- Prof. Gerry Wright
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36 min
24. Vaccines: a health insurance of the 21st century- Prof. Rino Rappuoli
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41 min
25. Biodefense vaccines- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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39 min
26. Vaccines in the modern world- Prof. Gordon Dougan
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39 min
27. Bacterial infection of epithelial signaling- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Acute lung injury
- ALI and ARDS: consensus definition
- ALI/ARDS and inflammation
- Inflammation in acute lung injury
- ALI: an inflammatory lung disease
- The paradox
- Selected basics of neutrophil biology
- Hematopoiesis
- Mature neutrophils
- The neutrophil: king of phagocytosis
- Phagocytosis (1)
- Phagocytosis (2)
- Neutrophil granules
- Phagocyte NADPH oxidase (NOX2)
- Neutrophil adhesion and emigration
- Back to the lung
- PMN sequestration mechanisms in ALI
- PMN sequestration in pulmonary capillaries
- PMN transiting a model capillary in vitro
- Leukocyte sequestration in ARDS
- Epithelial (epi.) function in lung injury
- Mechanisms and consequences of PMN migration
- Inter-epithelial cell junctions
- Inter-epithelial (i-epi.) junctional molecules
- In vitro model of PMN transmigration
- PMN transepithelial migration
- PMN migration creates areas of microinjury (1)
- PMN migration creates areas of microinjury (2)
- I-epi. junction disruption and neutrophil infiltration
- Elastase and trans-epithelial resistance decrease
- E-cadherin cleavage by PMN elastase
- Inter-epithelial junctional molecules cadherins
- Epi. injury mechanisms induces by PMN migration
- Epithelial apoptosis following PMN transmigration
- Elastase induces epithelial cell apoptosis (1)
- Elastase induces epithelial cell apoptosis (2)
- Mechanisms of elastase-induced apoptosis
- Pathways of apoptosis
- Elastase increases mitochondrial permeability
- Elastase induces cleavage of caspases 9 and 3
- Protease activated receptors
- PAR-1 siRNA blocks elastase-induced apoptosis
- Epithelial repair after ALI
- PMN transmigration: epithelial injury and repair
- Alterations in epithelial gene expression
- Ingenuity pathway analysis (1)
- Ingenuity pathway analysis (2)
- Wnt/beta-catenin pathway
- PMN transmigration induces beta-catenin signaling
- PMN migration induces beta-catenin translocation
- PMN transmigration induces TOPFlash activity
- Beta-catenin genes upregulated by PMN migration
- PMN migration and beta-catenin activation in vivo
- Beta-catenin dependent transcription and PMNs
- PMN migration induces cyclin D1 expression
- Functional role of beta-catenin in injury and repair
- ShRNA knockdown of beta-catenin
- Beta-catenin in epithelial injury and repair
- Conclusions
- The concepts discussed
- Therapeutic implications
- Acknowledgements
Topics Covered
- Clinical problem of acute lung injury and ARDS
- physiological role of neutrophils in host defense and innate immunity
- pathological role of neutrophils in inflammatory tissue injury in general and in acute lung injury
- mechanisms of damage to the lung epithelium by neutrophils
- paradoxical role of neutrophils in initiating repair processes
Links
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Talk Citation
Downey, G. (2011, July 27). Role of neutrophils in acute lung injury and repair [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/FGIM8341.Export Citation (RIS)
Publication History
- Published on July 27, 2011
Financial Disclosures
- Prof. Gregory Downey has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Role of neutrophils in acute lung injury and repair
Published on July 27, 2011
47 min
