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1. Introduction
2. Pregnancy and the immune system
3. SLE and flares during pregnancy
4. Pregnancies and patients studied
5. Flare definition applied in pregnancy
6. Physician judgement and disease activity index
7. Flare definition
8. Timing of SLE flares in pregnancy
9. Flare frequency by timing of pregnancy
10. ECLAM score / estrogen levels during pregnancy
11. Can we know flare occurrences in advance ?
12. Significant predictors of flares
13. Pregnant women with SLE can have flares
14. Gestational outcome in SLE
15. Impact of lupus activity on obstetric outcome
16. Gestational outcome in SLE: example
17. Gestational outcome in renal SLE
18. Identifying patients with a high risk of baby loss
19. Predictors of adverse pregnancy outcome
20. Predictors of obstetrical /neonatal complications
21. Factors that predict prematurity and preeclampsia
22. Autoantibodies that affect pregnancy outcome
23. Antiphospholipid (APL) antibody definition
24. Antiphospholipid (APL) antibody associations
25. Beta-2 glycoprotein I (beta-2GPI)
26. Two-hit theory in APS
27. Placenta: the target of aPL
28. Beta-2GPI binds the trophoblast cell membranes
29. Revised classification for APS syndrome
30. Antiphospholipid antibodies and autoimmunity
31. APS is treatable cause of prgnancy loss
32. Obstetrical complications
33. Newborns from mothers with primary APS (1)
34. Newborns from mothers with primary APS (2)
35. Thrombosis in the offspring of APS patients
36. Transplacental passage of IgG aPL (1)
37. Transplacental passage of IgG aPL (2)
38. aPL in 12 month old babies
39. The influence on fetal development
40. Mental developement and maternal autoAbs (1)
41. Mental developement and maternal autoAbs (2)
42. Clinical success and open questions
43. Register of infants from mothers with APS
44. IgG isotope can influence pregnancy
45. Ro complex
46. Anti-Ro/anti-La and autoimmunity
47. Anti Ro/SS-A and gestational outcome
48. Neonatal lupus model
49. Anti Ro/SS-A and congenital heart block (CHB)
50. Proposed mechanism of cardiac damage
51. The diagnosis of CHB
52. In utero detection of first-degree heart block
53. Management of CHB
54. Antenatal and postnatal exposure to DEX
55. 11 CHB children with/without exposure to DEX
56. T-cell evaluation in eight DEX exposed children
57. Heteroduplex analysis on TCRBV chains
58. Oligoclonal expansions of TCR repertoire
59. Alessa - case study
60. Second pregnancy - case study
61. Acknowledgements and contacts

Topics Covered

• Pregnancy and the immune system
• SLE flares during pregnancy
• Gestational outcome in SLE
• Predictors of obstetrical and neonatal complications in SLE
• Autoantibodies that can affect pregnancy outcome: antiphospholipid antibodies
• Obstetrical complications and newborns outcome in antiphospholipid syndrome
• Autoantibodies that can affect pregnancy outcome: anti-Ro/SS-A antibodies
• Neonatal lupus
• Congenital heart block and in utero exposure to dexamethasone

Links

Series:

• Autoimmunity

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Gynaecology & Obstetrics
• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Angela Tincani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.