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Printable Handouts
Navigable Slide Index
- Introduction
- Atherosclerosis (ATS)
- Pathogenetic steps in atherosclerosis
- Triggers and common pathway in atherosclerosis
- Features of innate and adaptive immunity in ATS
- Innate immunity factors involved in inflammatory
- CRP distribution within the atherosclerotic plaque
- CRP is a predictor of cardiovascular diseases
- Unstable carotid plaque (CARS)
- CD4+CD28null cells are expanded in angina
- CD4+CD28null lymphocytes are pro inflammatory
- CD4+CD28null in rheumatoid arthritis patients
- CD4+CD28null cells and increased IMT
- Atherosclerosis and autoimmunity
- Role of oxLDL in foam cells formation
- Anti-oxLDL and atherosclerosis
- Protective and pathogenetic anti-oxLDL
- Antiphospholipid antibodies
- Structure of beta-2GPI
- Surface charge and binding of beta-2GPI
- Beta-2GPI as a target for APL Abs
- Formation of oxLDL and beta-2GPI complex
- oxLDL/beta-2GPI as an inflammation marker
- The role of beta-2GPI in atherogenesis
- beta-2GPI localization in atherosclerotic plaques
- Immunization with beta-2GPI
- Antiphospholipid antibodies in ATS patients
- Example: protective role of anti-phospholipid Abs
- Human heat-shock proteins (HSP)
- Anti-heat shock protein (HSP) 60/65 antibodies
- Enhanced ATS and associated factors in ARD
- Atherosclerosis in RA - historical view
- Coronary artery disease in RA patients
- Coronary artery disease in SLE patients
- Incidence of MI in SLE patients
- Risk factors for atherosclerosis in SLE
- Non-invasive techniques for detection of ATS
- Duplex ultrasonography
- Intima-media thickness (IMT) in RA patients
- Risk factors for cardiovascular events
- Parallelism between RA and atherosclerosis
- Carotid ultrasound studies in SLE
- Traditional and other metabolic risk factors for ATS
- Cardiovascular risk in lupus
- Novel risk factors for atherosclerosis
- CRP and subclinical atherosclerosis in SLE
- The relationship between autoantibodies and ATS
- Subclinical atherosclerosis in SLE: study design
- M-IMT and IgG anti-oxLDL levels - correlation
- Mid conclusions
- Questions which should be addressed
- Correlates of accelerated atherosclerosis in SLE
- Who are at highest risk for accelerated ATS?
- Risk factors for carotid plaques in SLE
- 78 SLE patients
- PRD cumulative dosage in different patients
- PRD dosage - adjusted for traditional risk factors
- The bimodal mortality pattern of SLE
- Long-term prognosis in SLE
- Long-term prognosis in severe vs. mild SLE
- Take home message
- Conclusions
- Role of the endothelium in vascular homoeostasis
- Assessment of endothelial function
- Ultrasonography of brachial artery
- Endothelial dysfunction as predictor of CV events
- Endothelial dysfunction in autoimmune diseases
- Why does this correlation exist?
- Distant effects of local vascular inflammation
- Acknowledgments
Topics Covered
- Immunoinflammatory mechanisms involved in atherosclerosis
- Autoantibodies and atherosclerosis
- Clinical and subclinical atherosclerosis in rheumatoid arthritis
- Clinical and subclinical atherosclerosis in systemic lupus erythematosus
- Traditional and non-traditional risk factors for atherosclerosis in autoimmune rheumatic diseases
- Assessment of endothelial function in autoimmune rheumatic diseases
- Endothelial dysfunction in autoimmune rheumatic diseases
Links
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Talk Citation
Doria, A. (2007, October 1). Accelerated atherosclerosis in autoimmune rheumatic disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 12, 2024, from https://doi.org/10.69645/AYNB6698.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Andrea Doria has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.