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1. Introduction
2. Sjogren's syndrome
3. Major clinical manifestations
4. Lesions: major histopathologic findings
5. Why "autoimmine epithelitis"
6. The role of epithelium
7. Autoimmune phenomena: lesions
8. Salivary gland: immunopathology
9. Salivary gland epithelial cells (SGEC) - activation
10. SGEC culturing
11. SGEC: roles in immunity
12. Cultured SGEC - MHC expression
13. SGEC - B7 costimulatory molecules expression
14. 2 methods of showing B7 expression
15. Costimulation assay
16. B7 costimulate CD4+ T cells proliferation
17. B7 binds CD28 receptor, but not CTLA4
18. SGEC - roles in innate immunity
19. Toll-like receptors (TLRs)
20. Pattern recognition receptors (PRPs)
21. TLRs - activation of acquired immunity
22. Toll-like receptors expression
23. Function of toll-like receptors
24. TLRs on SGEC
25. SGEC - antigen release
26. Apoptosis
27. Increased apoptosis of epithelium in SS
28. SGEC - apoptosis in SS
29. Exosomes - origin
30. Exosomes - role
31. Exosomes in SGEC
32. SGEC exosomes contain autoantigens
33. SGEC participate in immune activation
34. Chronic viral sialadenitis mimicking SS
35. Candidate viruses
36. Viral proteins are found in LMSG tissues
37. Coxsackie viruses
38. Coxsackie viruses - infection
39. Coxsackie virus is associated with autoimmunity
40. Coxsackie viruses sequences in MSG biopsies
41. Coxsackie viruses - receptors
42. Coxsackievirus- adenonovirus receptor (CAR)
43. Decay-accelerating factor (DAF/CD55)
44. Other receptors
45. Coxsackie viruses - future directions
46. Summary
47. Acknowledgements

Topics Covered

• Characteristics and clinical symptoms of Sjogren's syndrome (SS)
• The epithelial component is the mainly affected tissue; injury is associated with dense lymphocytic infiltrates by activated T and B cells
• The epithelial cell is a pivotal regulator of the SS autoimmune responses
• SS is actually an autoimmune epithelitis
• Non-neoplastic salivary gland epithelial cell (SGEC) lines
• Epithelial cells possibly participate in the perpetuation of inflammatory responses and to the introduction of autoantigens in the immune system
• The critical role of epithelial cells in the regulation of local immune responses in salivary glands

Links

Series:

• Autoimmunity

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Haralampos Moutsopoulos has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.