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Printable Handouts
Navigable Slide Index
- Introduction
- What is 'M-current'?
- The M-current of a frog sympathetic neuron
- M-channels opening range
- Why 'M' current?
- The KCNQ/Kv7 family of potassium channels
- The M-channels' subunits
- How muscarinic receptors close M-channels
- Muscarinic receptors use 'remote signaling'
- The 'PIP2 hypothesis'
- M-channels depend on PIP2 to open
- Acetylcholine reduces the amount of PIP2
- PIP2 hydrolysis in a living neuron
- M-current inhibition by a muscarinic agonist
- Other M-current inhibitors
- Additional mechanisms of M-channel regulation
- Functions of M-channels
- M-current clamps membrane potential
- M-current reduces neurons' excitability
- M-current inhibition in synaptic transmission
- Nicotinic transmission in a rat ganglion
- Muscarinic transmission in a rat ganglion
- Muscarinic synaptic excitation in a rat ganglion
- Sensory systems and pain
- M-channel subunits in rat DRG
- M-current in rat nociceptive sensory neurons
- M-channel block's influence
- Peripheral nerves and hyper-excitability
- M-channels in mammalian nodes of Ranvier
- M-current block and nerve firing
- Electromyogram from rat tail muscle
- Mutations in the human KCNQ2 gene
- Effect of mutation in KCNQ2
- KCNQ2 mutation and channel behaviour
- Hippocampus and epilepsy
- Reduced spike frequency accommodation
- Enhanced spike after-depolarization - burst firing
- Spontaneous firing in hippocampal neurons
- M-current inhibition and spontaneous firing
- Location of M-channels
- Kv7 channels bind ankyrin-G via ABP
- Disruption of ankyrin-binding
- ABP reduces threshold for action potential
- M-channels and epilepsy
- BFNC mutation reduces M-current
- BFNC mutation (movie)
- Cerebral cortex: attention and cognition
- Methacholine inhibits M-current
- Facilitation of action potential discharges
- Cerebral cortex neurons and the nucleus basalis
- Cholinergic system - attention-directing modality
- Attention directing in the visual cortex
- Other points of interest
- Acknowledgments
Topics Covered
- Basic properties
- Molecular composition
- Inhibition by acetycholine and mechanism of inhibition
- Functions: membrane potential clamp
- Control of action potential discharges
- Control of nociceptive sensory excitation
- Suppression of repetitive discharges at nodes of Ranvier
- Regulation of action potential threshold at axon initial segment
- Suppression of epileptiform discharges in central neurons
- Contribution of M-channel inhibition to cholinergic excitation
Talk Citation
Brown, D.A. (2011, February 28). M-current and its role in neuronal physiology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2019, from https://hstalks.com/bs/1952/.Publication History
Financial Disclosures
- Prof. David A. Brown has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
M-current and its role in neuronal physiology
Published on February 28, 2011
39 min