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1. Introduction
2. What is 'M-current'?
3. The M-current of a frog sympathetic neuron
4. M-channels opening range
5. Why 'M' current?
6. The KCNQ/Kv7 family of potassium channels
7. The M-channels' subunits
8. How muscarinic receptors close M-channels
9. Muscarinic receptors use 'remote signaling'
10. The 'PIP2 hypothesis'
11. M-channels depend on PIP2 to open
12. Acetylcholine reduces the amount of PIP2
13. PIP2 hydrolysis in a living neuron
14. M-current inhibition by a muscarinic agonist
15. Other M-current inhibitors
16. Additional mechanisms of M-channel regulation
17. Functions of M-channels
18. M-current clamps membrane potential
19. M-current reduces neurons' excitability
20. M-current inhibition in synaptic transmission
21. Nicotinic transmission in a rat ganglion
22. Muscarinic transmission in a rat ganglion
23. Muscarinic synaptic excitation in a rat ganglion
24. Sensory systems and pain
25. M-channel subunits in rat DRG
26. M-current in rat nociceptive sensory neurons
27. M-channel block's influence
28. Peripheral nerves and hyper-excitability
29. M-channels in mammalian nodes of Ranvier
30. M-current block and nerve firing
31. Electromyogram from rat tail muscle
32. Mutations in the human KCNQ2 gene
33. Effect of mutation in KCNQ2
34. KCNQ2 mutation and channel behaviour
35. Hippocampus and epilepsy
36. Reduced spike frequency accommodation
37. Enhanced spike after-depolarization - burst firing
38. Spontaneous firing in hippocampal neurons
39. M-current inhibition and spontaneous firing
40. Location of M-channels
41. Kv7 channels bind ankyrin-G via ABP
42. Disruption of ankyrin-binding
43. ABP reduces threshold for action potential
44. M-channels and epilepsy
45. BFNC mutation reduces M-current
46. BFNC mutation (movie)
47. Cerebral cortex: attention and cognition
48. Methacholine inhibits M-current
49. Facilitation of action potential discharges
50. Cerebral cortex neurons and the nucleus basalis
51. Cholinergic system - attention-directing modality
52. Attention directing in the visual cortex
53. Other points of interest
54. Acknowledgments

Topics Covered

• Basic properties
• Molecular composition
• Inhibition by acetycholine and mechanism of inhibition
• Functions: membrane potential clamp
• Control of action potential discharges
• Control of nociceptive sensory excitation
• Suppression of repetitive discharges at nodes of Ranvier
• Regulation of action potential threshold at axon initial segment
• Suppression of epileptiform discharges in central neurons
• Contribution of M-channel inhibition to cholinergic excitation

Links

Series:

• Ion Channels

Categories:

• Biochemistry
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Brown, D.A. (2011, February 28). M-current and its role in neuronal physiology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2019, from https://hstalks.com/bs/1952/.

Publication History

• Published on February 28, 2011

Financial Disclosures

• Prof. David A. Brown has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.