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1. Introduction
2. Overview
3. Calcium cellular role
4. Tetrameric structure of CaV
5. Voltage gated calcium ion channel CaV
6. The network of CaValpha1 associated proteins
7. CaValpha1 genes expressed in mammals
8. Calcium channels and information flow
9. CaValpha1 genes to proteins
10. CaValpha1 protein pore opening
11. Distinguishing properties of CaValpha1 classes
12. Calcium currents through calcium channels
13. Comparing gating properties of CaV channels (1)
14. CaV2 current voltage relationship
15. Comparing gating properties of CaV channels (2)
16. Voltage gated calcium ion channel sub types (1)
17. CaV1 and gene expression
18. CaV1.1 channels as voltage sensors
19. Voltage gated calcium ion channel sub types (2)
20. Presynaptic CaV2 channels
21. Presynaptic CaV2 channels and GPCRs
22. GPCR use different pathways to inhibit CaV2
23. Voltage gated calcium ion channel sub types (3)
24. CaV3 T type channels in thalamic neurons
25. Mechanisms underlying diversity of CaV
26. Alternative pre mRNA splicing (1)
27. Alternative pre mRNA splicing (2)
28. Two patterns of alternative pre-mRNA splicing
29. RNA binding proteins control alternative splicing
30. Cell specific alternative splicing of pre-mRNAs
31. Known proteins controlling alternative splicing
32. Alternative splicing and CaValpha1
33. The mammalian CACNA1B genes
34. Expression patterns of alternatively spliced exons
35. CACNA1B splicing factors
36. The consequences of alternative splicing
37. CACNA1B splice site controls G protein coupling
38. Acknowledgements

Topics Covered

• Calcium
• Cellular Functions
• Voltage-gated calcium channels
• Functional and structural diversity
• Multiple subunits
• Multiple genes
• Gating, permeation, modulation
• Alternative pre-mRNA splicing
• cell-specific splicing factors
• CaV2.2 N-type channel
• Splicing and G protein inhibition

Links

Series:

• Ion Channels

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Lipscombe, D. (2011, February 28). Alternative splicing and calcium ion channel diversity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/NNNE9422.
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Publication History

• Published on February 28, 2011

Financial Disclosures

• Prof. Diane Lipscombe has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.