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- Diversity of Ion Channels
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36 min
1. The diversity and evolution of ion channels- Dr. Tim Jegla
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52 min
2. Alternative splicing and calcium ion channel diversity- Prof. Diane Lipscombe
- Ion Channel Structure and Function
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21 min
3. Functional modules in ion channels- Dr. Richard Horn
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54 min
4. Voltage-dependent gating of ion channels- Dr. Keith S. Elmslie
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39 min
5. M-current and its role in neuronal physiology- Prof. David A. Brown
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50 min
6. KATP channels and insulin secretion- Prof. Frances Mary Ashcroft
- Ion Channel Modulation
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53 min
7. Regulation of neuron accuracy by modulation of potassium channels- Prof. Leonard Kaczmarek
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82 min
8. Ion channel regulation by phosphorylation- Prof. Mike Shipston
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43 min
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29 min
10. Calcium regulation of ion channels- Prof. Geoffrey S. Pitt
- Ion Channels and Neuronal Plasticity
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48 min
11. Modulation of intrinsic neuronal excitability 1- Prof. Nelson Spruston
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45 min
12. Modulation of intrinsic neuronal excitability 2- Prof. Nelson Spruston
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33 min
13. Glutamate receptor modulation and long-term synaptic plasticity- Prof. Graham Collingridge
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44 min
14. Cellular mechanisms of neuromodulation in a small neural network- Prof. Ronald M. Harris-Warrick
- Ion Channels and Disease
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30 min
15. Kv10.1 potassium channels in cancer- Prof. Luis Pardo
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51 min
- Archived Lectures *These may not cover the latest advances in the field
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43 min
17. KV10.1 potassium channels in cancer- Prof. Luis Pardo
Printable Handouts
Navigable Slide Index
- Introduction
- What are ion channels?
- All physiological processes require ion channels
- Ion channels are selective
- Channels are gated
- Voltage gating
- Ligand gating
- Sensory gating
- Phototransduction relies on ligand-gated channels
- Ion channels in the human genome
- Channels vs. transporters
- Highlights of the human channel set
- Four-fold symmetric ion channels
- Ion channels with other symmetry
- Subunit topology and arrangement
- A fundamental set of eumetazoan ion channels
- The voltage-gated cation channel superfamily
- Evolution of the nervous system
- Prokaryotes
- Choanoflagellates (1)
- Choanoflagellates (2)
- Sponge
- Cnidarians have it all
- What are Cnidarians doing with all channels?
- Mammalian channel genes
- Evolution of mammalian GABA-A receptors
- Summary
- New ion channels waiting to be discovered
- Acknowledgements
Topics Covered
- What are ion channels and why are they important?
- Ion channels have diverse selectivity and gating
- Human channel diversity and structures
- A fundamental set of ion channels in animals
- How our voltage-gated ion channels evolved
- How are our ion channel gene families made?
Talk Citation
Jegla, T. (2011, February 28). The diversity and evolution of ion channels [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/KOJE5705.Export Citation (RIS)
Publication History
- Published on February 28, 2011
Financial Disclosures
- Dr. Tim Jegla has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The diversity and evolution of ion channels
Published on February 28, 2011
36 min
