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1. Introduction
2. Biological basis
3. How does resistance develop?
4. Codon and amino acid changes
5. Mutations
6. Virological response to antiretroviral therapy
7. Genotypic and phenotypic resistance
8. Mutations selected by PIs
9. HIV-1 protease bound to an inhibitor
10. Clinical implications
11. Resistance accumulates
12. Mutations in patients with virologic failure
13. Viral rebound rarely reaches pre-therapy levels
14. AZT mutations, TAMS, NAMS, etc...
15. NRTI resistance (1)
16. NRTI resistance (2)
17. Protease inhibitors
18. Major vs. minor PI mutations
19. Protease mutations
20. Concentration-time profile: PK enhancement
21. Overcoming drug resistance
22. Pathways to clinical resistance - NNRTI
23. Summary

Topics Covered

• HIV replication and biological basis of drug resistance
• Antiviral drugs
• Emergence of drug resistance in practice
• Measurement of drug resistance

Links

Series:

• Antibiotic Resistance

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on January 16, 2011

Financial Disclosures

• Prof. Deenan Pillay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.