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Printable Handouts
Navigable Slide Index
- Introduction
- Ubiquitination vs. phosphorylation (1)
- Ubiquitination vs. phosphorylation (2)
- Ubiquitination vs. phosphorylation (3)
- Ubiquitin-binding domains
- Ubiquitination vs. phosphorylation (4)
- Ubiquitin signaling in the NF-kappaB pathway
- NF-kappaB signaling pathway
- The biochemical pathway of IkB ubiquitination (1)
- The biochemical pathway of IkB ubiquitination (2)
- The IL-1R/toll-like receptor pathway
- TRAF-6, Nemo-dependent IKK activation in vitro
- Activation of IKK by TRAF6 requires two factors
- TRAF6-regulated IKK activator-2
- Ubc13 is required for IKK activation by IL-1beta
- Catalytic activity of Ubc13
- TRIKA1 = Ubc13/Uev1A
- Domain organization of TRAFs
- TRAF6 is a ubiquitin ligase
- Polyubiquitin chains
- K63-linked polyUb chains mediate IKK activation
- Human ubiquitin genes
- An inducible ubiquitin "knock-in" system
- K63 is required for IKK activation by IL-1beta
- TRIKA2 = TAK1/TAB1/TAB2
- Ubiquitin activation of stress kinases
- The proposed model
- The CYLD and NEMO pathologies
- Innate and adaptive immunity
- Acknowledgement
Topics Covered
- Ubiquitination is a reversible covalent modification, akin to phosphorylation
- Ubiquitination regulates protein kinase activity through proteasome-independent mechanisms
- K63-linked polyubiquitination activates TAK1 and IKK in the NF-kappaB pathway
- Deubiquitination enzymes inhibit protein kinases in the NF-kappaB pathway
- Protein kinase regulation by ubiquitin is important in innate and adaptive immunity
Talk Citation
Chen, Z.'. (2010, November 30). The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/PGQM8626.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Zhijian 'James' Chen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway
Published on November 30, 2010
30 min
A selection of talks on Biochemistry
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