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Printable Handouts
Navigable Slide Index
- Introduction
- Kinases and phosphatases
- Ways to remove phosphate from proteins
- Class I Cys-based PTPs
- Phosphatase families
- Human genome
- Mutational analysis of PTP-1
- Sequences at active site (1)
- Phospho-enzyme intermediate
- pH stability of phosphoprotein phosphate
- Site-directed mutational analysis of VHR
- PTPs share a catalytic active site motif
- Sequences at active site (2)
- Sequences of phosphatases
- Yop 2b
- The bacterial Yop 2b phosphatase activity
- Bacterial growth in the spleen of mice
- Yop 2b in eukaryotic macrophages
- Yersinia inject phosphatase into eukaryotic cells (1)
- Yersinia inject phosphatase into eukaryotic cells (2)
- Interaction between Yersinia and a target cell
- Phosphatases as tumor suppressor genes
- Lab members that researched PTEN
- PTEN and myotubularin structure
- PTEN - 10q23.3
- Frequency of PTEN mutations
- Kinetic constants of dual-specificity phosphates
- PTEN is a "lipid" phosphatase
- PTEN might inhibit cell survival
- Effect of PTEN overexpression on PIP3 production
- Effect of PTEN expression on PI 3-kinase activation
- Inositol phosphatase activity of PTEN
- PTEN tumor suppressor activity
- PTEN and PIP3 researchers
- RNA interference first developed in C.elegans
- RNA interference protocol for fly S2 cells
- Mammalian, C.elegans and fly signaling cascade
- PTEN inhibits Akt activity
- Crystal structure of PTEN
- The active site pocket of PTEN
- Sequence alignment of PTEN catalytic site
- Structure of PTEN
- Summary
Topics Covered
- Kinases and phosphatases
- Ways to remove phosphate from proteins
- Class I Cys-based PTPs
- Phosphatase families
- Mutational analysis of PTP-1
- Sequences at active site
- Phospho-enzyme intermediate
- pH stability of phosphoprotein phosphate
- Site-directed mutational analysis of VHR
- How PTPs share a catalytic active site motif
- Sequences of phosphatases
- The bacterial Yop 2b phosphatase activity
- Bacterial growth in the spleen of mice
- Yop 2b in eukaryotic macrophages
- Interaction between Yersinia and a target cell
- Phosphatases as tumor suppressor genes
- PTEN and myotubularin structure
- PTEN-10q23.3
- Frequency of PTEN mutations
- Kinetic constants of dual-specificity phosphates
- How PTEN is a "lipid" phosphatase
- How PTEN might inhibit cell survival
- Effect of PTEN overexpression on PIP3 production
- Effect of PTEN expression on PI 3-kinase activation
- Inositol phosphatase activity of PTEN
- PTEN tumor suppressor activity
- Key PTEN and PIP3 researchers -RNA interference in C.elegans
- RNA interference protocol for fly S2 cells
- Mammalian, C.elegans and fly signaling cascade
- How PTEN inhibits Akt activity
- The active site pocket of PTEN
- Sequence alignment of PTEN catalytic site
Talk Citation
Dixon, J. (2010, November 30). Protein tyrosine phosphatases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/PLIV5539.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jack Dixon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.