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1. Introduction
2. Part II: the NKG2D-DAP10 signaling complex
3. The human NKG2D-DAP10 complex
4. Importance of YINM motif in DAP10 signaling
5. Coupling to p85 and Grb2/Vav
6. Grb2: signaling and activation
7. PI3K is required for NKG2D-mediated killing
8. CrkL regulates conjugate formation
9. Rap1 activation by NKG2D
10. JNK1 activation by NKG2D
11. Summary of part II
12. Part III: inhibitory receptor signaling
13. iKIR crosslinking leads SHP1 recruitment
14. SHP1 binds directly to the ITIM motif
15. iKIR engagement blocks signaling
16. Catalytically-inactive SHP1 leads to cell death
17. What are the targets of SHP1?
18. Vav1 is a target of SHP1
19. Summary of part III
20. Acknowledgements

Topics Covered

• Regulation of killing by the NKG2D/DAP10 receptor complex
• PI3K pathway regulates cell adhesion and MTOC polarization through a CrkL-Rap1 activation
• Grb2/Vav1 pathway regulates SLP-76 and PLCγ2 activation, calcium signaling and cell-mediated killing
• Inhibitory signaling from killer immunoglobulin receptors that recruit the tyrosine phosphatase SHP1
• SHP1 targets

Links

Series:

• Natural Killer Cell Biology

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Billadeau, D. (2010, October 20). NK cell signaling to cytotoxicity - parts II & III [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 17, 2025, from https://doi.org/10.69645/CYLP8916.
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Publication History

• Published on October 20, 2010

Financial Disclosures

• Prof. Dan Billadeau has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.