Mammalian flavin-containing monooxygenases

Published on July 8, 2010 Updated on September 30, 2015   34 min

Other Talks in the Series: Drug Metabolizing Enzymes

Hello, and welcome to this presentation on mammalian flavin-containing monooxygenases, which we'll abbreviate as FMOs. The FMOs represent an enzyme family that's an important component of the body's armamentarium of oxidative drug metabolizing enzymes. I am Allen Rettie. And I will be your guide for this topic through the next 40 minutes.
Today's lecture will be divided into six main sections dealing with the structure, mechanism, enzyme multiplicity, gene regulation, and substrate specificity of the mammalian FMOs. We will also devote time to discussing experimental methods that permit the differentiation of FMO catalysis from that of the cytochrome P450s, both of which are present in the microsomal fraction of the cell. The presentation will conclude with suggestions for future research but begin with some historical background and an overview of the enzyme's general characteristics.