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Printable Handouts
Navigable Slide Index
- Introduction
- Genomic imprinting overview
- Nuclear transplantation in the mouse
- Uniparental development in humans
- Uniparental disomy
- Mouse imprinted genes, regions and phenotypes
- Human and mouse imprinted regions
- The mark of imprinted genes
- Properties of the mark
- Candidates for the mark
- Is DNA methylation the imprinting mark?
- H19 and Igf2 imprinted locus
- The mouse H19 gene is differentially methylated
- DNA methylation at the H19 locus
- H19 and Igf2 share enhancers
- Deletion of Dnmt1 activates the paternal H19
- H19 is biallelically expressed in Dnmt1 -/- embryos
- Insulator mechanism
- Insulators: barriers and enhancer blockers
- Insulator model for imprinted genes - H19 Igf2 locus
- Long non-coding RNA mechanism of imprinting reg.
- Imprinted genes summary
- When and how are genes marked in the germline?
- DNA methylation erasure in embryonic germ cells
- Methylation at the Snrpn ICR in growing oocytes
- The hypothesis
- How are imprints maintained?
- Summary
Topics Covered
- Genomic Imprinting: Definition of genomic imprinting
- Why genomic imprinting is essential for development
- Imprinted genes
- Mechanism of genomic imprinting
- H19/Igf2 imprinted locus
- Marking of imprinted genes in the germline
- Maintenance of genomic imprints
Talk Citation
Bartolomei, M. (2011, March 3). Genomic imprinting [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/MSAE3986.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Marisa Bartolomei has no commercial/financial relationships to disclose