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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- The thyroid hormone and mitochondrial biogenesis
- Generation and delivery of thyroid hormone
- Secretion of thyroid hormones
- Thyroxine (T4)
- Activation by deiodination
- Regulation of gene expression by thyroid hormone
- Regulation by thyroid hormone receptors
- Connection between TR and chromatin structure
- Nuclear and mitochondrial gene expression by TR
- Expression kinetics of T3 target genes
- Different kinetics = different mechanisms?
- A candidate for an intermediate factor of T3 action
- Intermediate factor = PGC-1-alpha ?
- Non-genomic regulation by thyroid hormone (1)
- Non-genomic regulation by thyroid hormone (2)
- Different THs have different specificities
- Non-genomic regulation pathways of thyroid
- Thyroid hormone metabolism
- Back to the thyroid hormone metabolism
- 3 types of deiodinases
- Multiple deiodination products
- Thyroid hormone and thyroid hormone impact
- Of particular interest: 3,5-T2
- Thyronamine: thyroid decarboxylation products
- Summary
Topics Covered
- Synthesis of thyroid hormone (TH)
- Local bioavailability
- Conversion of thyroxine by deiodination
- TH and gene expression
- Molecular readout of TH
- TH and chromatin structure
- Non-genomic effects of TH
- Extra-cellular binding to integrins
- TH metabolism
- TH derivatives
- TH derivatives and their impact on mitochondrial biogenesis
- Thyronamines
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Talk Citation
Weitzel, J. (2022, April 12). Thyroid hormone and mitochondrial biogenesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/BRQZ7239.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Joachim Weitzel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Thyroid hormone and mitochondrial biogenesis
A selection of talks on Cell Biology
Transcript
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0:00
This presentation will deal with the connection
between thyroid hormones and mitochondrial biogenesis.
0:10
Presentation is divided into the following six parts.
First, I would like to address the connection between
thyroid hormones and mitochondrial biogenesis.
Next, I would like to focus on the generation and delivery of thyroid hormone.
Third, the regulation of gene expression which is mediated by thyroid hormone.
And the regulation of thyroid hormones which are non genomically.
Then I would like to point to the thyroid hormone metabolism.
And finally, to the impact of thyroid hormone and
thyroid hormone derivatives on mitochondrial biogenesis.
0:58
There are multiple direct connections between
thyroid hormone and mitochondrial biogenesis.
Thyroid hormone triggers for example;
increased pulse rate and heart weight.
They lead to an increased energy substrate uptake and utilization,
they increased the total energy consumption,
they increased the cellular respiratory rates among others.
All these effects are closely connected to mitochondrial biogenesis.
1:36
Let's focus to the generation and delivery of thyroid hormones.
Thyroid hormones were synthesized in