• Cellular Mechanisms of Mitochondrial Biogenesis in Health
• 23 min
  1. Nuclear control of electron transport chain gene expression

  • Dr. Glenn C. Rowe
• 48 min
  2. Regulation of mitochondrial biogenesis by transcriptional coactivators and estrogen-related receptor alpha

  • Dr. Anastasia Kralli
• 17 min
  3. Protein import into mitochondria

  • Dr. Trevor Lithgow
• 39 min
  4. Mitochondrial phospholipid synthesis and incorporation

  • Prof. Grant Hatch
• 23 min
  5. Mitochondrial DNA replication and transcription

  • Prof. Julio Montoya
• 37 min
  6. Mitochondrial production of reactive oxygen species 1

  • Prof. Martin Brand
• 22 min
  7. Mitochondrial production of reactive oxygen species 2

  • Prof. Martin Brand
• 35 min
  8. Mitophagy - the degradation of dysfunctional organelles

  • Dr. Anna Vainshtein
• Mitochondrial Biogenesis in Physiological Conditions
• 21 min
  9. Thyroid hormone and mitochondrial biogenesis

  • Dr. Joachim Weitzel
• 28 min
  10. Exercise-induced mitochondrial biogenesis in muscle 1

  • Prof. David Hood
• 37 min
  11. Exercise-induced mitochondrial biogenesis in muscle 2

  • Prof. David Hood
• Mitochondrial Biogenesis in Aging and Disease
• 33 min
  12. Mitochondrial diseases: an update

  • Dr. Ayesha Saleem
• 59 min
  13. Exercise and nutrition in mitochondrial disorders

  • Prof. Mark Tarnopolsky
• 42 min
  14. Mitochondrial disorders and neurodegeneration

  • Dr. Jan-Willem Taanman
• 33 min
  15. Reprogramming oxidative phosphorylation in cancer

  • Prof. José Cuezva
• 44 min
  16. Possible roles of mitochondrial biogenesis in aging

  • Dr. Aubrey de Grey
• 31 min
  17. Mitochondria in reproduction and fertility: mitochondria and gametes 1

  • Prof. Pascale May Panloup
• 30 min
  18. Mitochondria in reproduction and fertility: mitochondria and embryo 2

  • Prof. Pascale May Panloup
• 35 min
  19. Mitochondrial morphology and ultrastructure in skeletal muscle

  • Prof. Martin Picard
• 19 min
  20. Improving mitochondrial phenotypes with pharmaceuticals

  • Prof. Christopher Perry
• Mitochondria, Cell Signaling and Apoptosis
• 42 min
  21. Mitochondrial permeability transition

  • Prof. John Lemasters
• 47 min
  22. Pathways of apoptosis in muscle 1

  • Prof. Stephen E. Alway
• 42 min
  23. Pathways of apoptosis in muscle 2

  • Prof. Stephen E. Alway
• 21 min
  24. Controlling mitochondrial reactive oxygen species production for cell signaling 1

  • Dr. Ryan J. Mailloux
• 32 min
  25. Controlling mitochondrial reactive oxygen species production for cell signaling 2

  • Dr. Ryan J. Mailloux
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  26. Reactive oxygen species and myocardial apoptosis

  • Dr. Zhi-Qing Zhao
• 34 min
  27. Mitochondrial biogenesis as a result of exercise

  • Dr. Darrell Neufer
• 30 min
  28. Mechanisms of mitochondrial fusion and fission

  • Dr. Luca Scorrano
• 30 min
  29. Mitochondrial heterogeneity in cells

  • Dr. Tony Collins
• 40 min
  30. Mitochondrial diseases: an update

  • Prof. Salvatore DiMauro
• 41 min
  31. Calcium signaling and mitochondrial function

  • Prof. David Nicholls
• 35 min
  32. Mitochondrial biogenesis during gametogenesis and embryonic development

  • Prof. Pascal Reynier
• 33 min
  33. Mitochondrial complex assembly

  • Dr. Leo Nijtmans
• 33 min
  34. Evolutionary and developmental variation in muscle mitochondrial content

  • Prof. Christopher Moyes
• 33 min
  35. Muscle mitochondrial function and biogenesis with aging

  • Dr. Russell Hepple
• 23 min
  36. The mitochondrial pathway in apoptosis

  • Prof. Douglas Green
• 40 min
  37. Nuclear control of respiratory chain expression by transcriptional activators and coactivators

  • Prof. Richard Scarpulla
• 38 min
  38. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 43 min
  39. Respiration, reactive oxygen species and uncoupling proteins

  • Prof. Martin Brand

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Nucleo-mitochondrial interactions
3. Nuclear and mitochondrial respiratory subunits
4. Mammalian somatic cytochrome c genes
5. Identification of NRF-1
6. NRF-1 functional domains
7. NRF-2, an activator of COXIV expression
8. NRF-2 functional domains
9. NRF-2 binding sites
10. Comparison of NRF target genes
11. Partial list of NRF target genes
12. Promoter occupancy by NRF-2
13. NRF-1 knockout allele
14. NRF-1 genotypes
15. Properties of NRF-1(-/-) blastocysts
16. Mitochondrial transcription factors
17. Transcription factor promoters
18. Comparison of TFB NRF-1 sites
19. Alignment of TFB NRF-2 sites
20. NRF control over TFB promoters
21. NRF control of mitochondrial transcription
22. Transcription factors and bioenergetic phenotype
23. Transcriptional co-activators
24. Functional domains in PGC-1-alpha (92 kDa)
25. Metabolic regulation by PGC-1-alpha
26. PGC-1-related co-activator (PRC)
27. Activator/coactivator interactions
28. PRC functional interaction with NRF-1
29. Trans-activation of TFB expression
30. Coactivator induction during thermogenesis
31. PRC expression and cell growth
32. Protein synthesis and PRC mRNA expression
33. Immediate early expression of PRC
34. Serum-induced gene expression
35. Respiratory response to serum
36. Pathways of CREB signaling
37. Binding of NRF-1 and CREB to PRC
38. NRF-1/PRC and CREB/PRC complexes
39. Summary of in vitro binding
40. Quantitative ChIP analysis
41. Cytochrome c promoter occupancy
42. Model for growth induction
43. Integrative role for PRC in cell growth
44. Coactivator control of cell metabolism

Topics Covered

• Contribution of nuclear and mitochondrial genomes to respiratory chain expression
• Genomic origin of respiratory chain subunits
• Cytochrome c as a model for respiratory gene expression
• DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2)
• Identification and characterization of NRF target genes
• Phenotypes associated with a targeted disruption of NRF-1 in mice
• NRF control of mitochondrial transcription factor expression
• The PGC-1 family
• PRC functional interactions with NRF-1 and CREB
• Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth
• Potential role for PRC in integrating mitochondrial functions with cell growth

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Scarpulla, R. (2007, October 1). Nuclear control of respiratory chain expression by transcriptional activators and coactivators [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 11, 2025, from https://doi.org/10.69645/CWNJ6308.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on June 30, 2019

Financial Disclosures

• Prof. Richard Scarpulla has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.