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We hope you have enjoyed this limited-length demo
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- Clinical Introduction
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1. Frontotemporal dementia
- Prof. Bruce Miller
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2. Parkinson disease
- Prof. Stanley Fahn
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3. Atypical parkinsonian syndromes
- Dr. David Burn
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4. Huntington's disease
- Prof. Roger Barker
- Neuroimaging
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5. Molecular brain imaging (PET) in diseases with dementia
- Prof. Karl Herholz
- Pathology, Genetic and Molecular Aspects (1)
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6. A molecular understanding of Alzheimer's disease
- Prof. John Hardy
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7. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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9. Ubiquitination and Alzheimer related disorders
- Prof. John Mayer
- Pathology, Genetic and Molecular Aspects (2)
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10. The molecular biology of Huntington's disease
- Prof. David C. Rubinsztein
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11. Metals, oxidative stress and neurodegeneration
- Prof. Ashley Bush
- Latest Developments in the Field
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12. Animal models of tauopathy
- Prof. David Westaway
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13. Parkinson's disease and transplants
- Prof. Roger Barker
- Archived Lectures *These may not cover the latest advances in the field
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14. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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15. Motor neurone disease: molecular basis
- Prof. Kevin Talbot
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16. Alzheimer's disease (AD)
- Prof. John Hodges
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17. Frontotemporal dementia syndromes
- Prof. John Hodges
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18. Motor neurone disease: clinical aspects
- Prof. Kevin Talbot
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19. Neuro-imaging in dementia: using MRI in routine work-up
- Prof. Philip Scheltens
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20. Prion diseases
- Prof. Pierluigi Gambetti
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21. Mitochondrial disorders and neurodegeneration
- Prof. Anthony Schapira
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23. Mutations in parkinsonian syndromes
- Dr. Andrew Singleton
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25. Frontotemporal dementia
- Prof. Bruce Miller
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Prevalence
- Neary criteria
- Variants of FTD
- Tau positive and tau negative variants
- Tau immunopositive inclusions
- Inclusions in sporadic ALS
- Is FTD genetic?
- Progranulin a new FTD gene
- Progranulin haploinsufficiency
- VBM analysis of FTLD with progranulin mutations
- Progranulin gene structure
- Progranulin highly expressed in peripheral blood
- The syndrome
- The region
- The circuit
- Cells, molecules and genes
- FTD atrophy by clinical stage
- Von Economo neuron (VENs) ACC and FI
- VENs
- Vens: vulnerable neuron in FTD?
- Regions unique to individual behaviors
- Overeating in FTD
- Evolution of the "self"
- Development of self - mirror studies
- Development of self
- Startle in FTD
- Traditional frontal neuropsychology
- Amyloid imaging
- Research criteria for FTD
- Conclusions
- Acknowledgements
Topics Covered
- Prevalence and nomenclature of FTD
- The pathology of FTD (tau, TDP-43)
- The genetics of FTD (tau, progranulin)
- Patterns of atrophy and neuroanatomical correlates of behavior and cognition
- von Economo neurons
- Neuroimaging (amyloid imaging)
- Treatment
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Miller, B. (2010, February 14). Frontotemporal dementia [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/MHXQ2297.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Bruce Miller has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.