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1. Introduction
2. Fitness and resistance
3. Assessment of growth rate/fitness
4. Growth formula
5. Bacteria growth experience illustration
6. Comparative method illustration
7. Relative fitness of resistant M. tuberculosis
8. Relative fitness and number of clinical isolates
9. Relative fitness in medium vs. macrophages
10. Other measures of fitness
11. Fit the measure to the specie - Staphylococci
12. Resistance not always results in fitness-deficit (1)
13. Resistance not always results in fitness-deficit (2)
14. Another method for testing fitness
15. Genetic background influence on growth
16. Sequential passage methodology
17. Results of passage for 88 generation
18. In vivo adaptation
19. Spectra of compensated mutants isolated
20. Adaptation occurs readily in humans
21. Genetic basis for resistance and fitness
22. Conclusion

Topics Covered

• Fitness and resistance
• Assessment of growth rate/fitness
• Sequential passage methodology
• In vivo adaptation
• Transmission of strains
• Bacteria rapidly adapt

Links

Series:

• Antibiotic Resistance

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on January 13, 2010

Financial Disclosures

• Prof. Stephen Gillespie is in receipt of research grants from MMRC, EDCTP, Global Alliance for TB Drug Development. Professor Gillespie’s involvements in clinical trials are supported by active and placebo drug supplies from Bayer Schering Health Care and Sanofi Aventis, while also providing support with regulatory and drug safety advice. Neither company has a managerial role within the study, however. Professor Gillespie has also provided training to senior staff at Bayer Schering Health Care.