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- Evolutionary Perspectives
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42 min
1. Antibiotic resistance: a mechanistic overview- Dr. Neil Woodford
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20 min
2. Mutation- Prof. Stephen Gillespie
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11 min
3. Fitness in antibiotic resistant bacteria- Prof. Stephen Gillespie
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34 min
4. Fitness and compensation- Dr. Sébastian Gagneux
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22 min
5. Antibiotic resistance and the supragenome hypothesis- Dr. Bambos Charalambous
- Epidemiology and Clinical Impact
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37 min
6. Methicillin resistant S. aureus and other resistances- Prof. Mark Enright
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43 min
7. Risk factors for antibiotic resistance in Streptococcus pneumoniae- Prof. Keith Klugman
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38 min
8. Beta-lactamases: clinical impact and epidemiology- Prof. Sebastian Amyes
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49 min
9. Glycopeptide-resistant enterococci- Dr. Neil Woodford
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33 min
10. Drug resistant tuberculosis: biology, epidemiology and control- Dr. Christopher Dye
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26 min
11. Antiretroviral drug resistance- Prof. Deenan Pillay
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49 min
12. Malaria - changing paradigms- Dr. Janet Cox-Singh
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42 min
13. Advances in mode of action of antimalarials and resistance mechanisms 1- Prof. David Warhurst
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38 min
14. Advances in mode of action of antimalarials and resistance mechanisms 2- Prof. David Warhurst
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15. HCV resistance- Prof. John Dillon
- Diagnosis and Surveillance of Resistance
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29 min
16. Conventional and automated diagnostic methods- Dr. Alan Johnson
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38 min
17. National and international surveillance of antibiotic resistance 1- Prof. David Livermore
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50 min
18. National and international surveillance of antibiotic resistance 2- Prof. David Livermore
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24 min
19. Innovative approaches to rapid antibiotic resistance testing- Dr. Robert Hammond
- Controlling Antibiotic Resistance
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39 min
20. Controlling antibiotic resistance in the hospital environment- Dr. Ian Eltringham
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27 min
21. Controlling antibiotic resistance in the community- Dr. Peter Wilson
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51 min
22. Public policy to reduce antibiotic resistance- Dr. Niels Frimodt-Møller
- The Antibiotic Resistance Future
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26 min
23. Overcoming resistance through novel drug targets- Prof. Anthony Coates
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37 min
24. Medicinal chemistry strategies in combating antibiotic resistance- Dr. Geoffrey Coxon
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36 min
25. Teixobactin kills pathogens without detectable resistance- Prof. Kim Lewis
- Archived Lectures *These may not cover the latest advances in the field
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48 min
26. Molecular diagnosis of antibiotic resistance- Dr. Tim McHugh
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36 min
27. Introduction to malaria- Prof. David Warhurst
Printable Handouts
Navigable Slide Index
- Introduction
- Factors to study in the evolution of resistance
- Antibiotic resistance by chromosomal mutation
- Mutation
- Likelihood of resistance emerging
- Diagram - a "jackpot" culture
- Diagram - a late mutation
- Diagram - which has the highest mutation rate?
- Mutation rate and mutation frequency - summary
- Determining mutation rate
- Overview on mutation rate experiments (1)
- Overview on mutation rate experiments (2)
- Range of detected mutations in an experiment
- MICs of different mutant strains of S. pneumoniae
- Parameters for planning mutation rate experiments
- Methods of calculation of mutation rates
- Variables for the calculation of mutation rate
- Equations used in the calculation of m
- Calculating mutation rate
- What do we mean by mutation rate?
- Assumptions in a fluctuation analysis
- Does cell state affect the mutation rate?
- No increase in mutation rate in low pH
- Chemostat at pH=7
- Chemostat at pH=6.2
- Hypermutability
- Rifampicin mutation frequency in CF patients
- Antibiotic resistance in CF patients
- Mutator strains belonging to E. coli and Shigella
- Mutator strains more likely to generate resistance
- Identifying mutator strains
- Mutation rates for first- and second-step mutants
- Antibiotics can increase mutation rate
- Case report of antibiotic resistance
- Reservoir of mutants in untreated patients
- Mutations in gyrA, parC
- Summary
Topics Covered
- Factors to study in the evolution of resistance
- Antibiotic resistance by chromosomal mutation
- Likelihood of resistance emerging
- Determining mutation rate
- Parameters for planning a mutation rate experiment
- Methods of calculating mutation rate
- Assumptions in a fluctuation analysis
- Environmental stresses in the host environment
- Hypermutability
Talk Citation
Gillespie, S. (2010, January 13). Mutation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 24, 2025, from https://doi.org/10.69645/NLWY7843.Export Citation (RIS)
Publication History
- Published on January 13, 2010
Financial Disclosures
- Prof. Stephen Gillespie is in receipt of research grants from MMRC, EDCTP, Global Alliance for TB Drug Development. Professor Gillespie’s involvements in clinical trials are supported by active and placebo drug supplies from Bayer Schering Health Care and Sanofi Aventis, while also providing support with regulatory and drug safety advice. Neither company has a managerial role within the study, however. Professor Gillespie has also provided training to senior staff at Bayer Schering Health Care.
