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- Fundamentals of Evolution and Medicine
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1. Evolutionary medicine
- Prof. Randolph Nesse
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2. Evolution and medicine: from the perspective of an evolutionary biologist
- Prof. Stephen C. Stearns
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3. Developmental plasticity, evolution and the origins of disease
- Dr. Mary Jane West-Eberhard
- Evolutionary Genetics
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4. Genetic variation and human disease
- Dr. David Houle
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6. Ecogenetics, evolutionary biology and human disease
- Prof. Gilbert Omenn
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7. Race in genetics and medicine
- Prof. Jeffrey Long
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8. Health disparities in common complex diseases: a role for genetics?
- Dr. Kathleen Barnes
- Infectious Disease
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10. Evolutionary arms races
- Prof. Mark Pagel
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11. Antibiotic resistance and hospital-acquired infection
- Dr. Carl Bergstrom
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12. Evolution of drug resistance
- Dr. Pleuni Pennings
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13. Evolution of virulence: malaria, a case study
- Prof. Andrew Read
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14. Infection and chronic disease
- Prof. Paul Ewald
- Defenses
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15. Fever and related defenses
- Prof. Matthew Kluger
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16. The evolutionary ecology of immunity
- Prof. Paul Schmid-Hempel
- Novel Environmental Factors
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17. What did humans evolve to eat? evolutionary perspectives on human nutritional health
- Prof. William R. Leonard
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19. The paleolithic lifestyle and prevention of chronic disease
- Prof. S. Boyd Eaton
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22. Diseases of civilization: an evolutionary legacy
- Prof. Alan Weder
- Problems Arising From Constraints and Trade-Offs
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23. Aging and evolutionary medicine
- Prof. Linda Partridge
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24. Human aging and menopause
- Prof. Kristen Hawkes
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25. Why we cook with spices: preventative darwinian medicine
- Prof. Paul Sherman
- Sex and Reproduction
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26. Setting the second stage: the evolution of menopause & post-reproductive life
- Prof. Lynnette Sievert
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27. Evolutionary obstetrics
- Prof. Wenda Trevathan
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28. Sex differences in mortality
- Dr. Daniel Kruger
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29. The endocrinology of human life history transitions
- Prof. Peter Ellison
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30. Genetic conflicts in human pregnancy
- Prof. David Haig
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31. Environmental effects on human reproduction
- Prof. Gillian Bentley
- Cancer
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32. A darwinian eye view of cancer
- Prof. Mel Greaves
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33. Viruses and cancer
- Prof. Robin Weiss
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34. Connecting aging and cancer through the lens of evolution
- Prof. James DeGregori
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35. Evolutionary dynamics in cancer control and cure
- Dr. Bob Gatenby
- Specific Body Systems
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36. Hard tissue biology in human health and evolution: enamel biology
- Prof. Timothy Bromage
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37. Hard tissue biology in human health and evolution: bone biology
- Prof. Timothy Bromage
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38. Hard tissue biology in human health and evolution: craniofacial biology
- Prof. Timothy Bromage
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39. Hard tissue biology in human health and evolution: life history and chronobiology
- Prof. Timothy Bromage
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40. Lung biology and lung disease
- Prof. John S. Torday
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41. The evolutionary web of life
- Prof. John S. Torday
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42. Evolutionary considerations and the endothelium
- Dr. William Aird
- Mental Disorders
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43. Evolutionary psychiatry
- Prof. Randolph Nesse
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44. Evolutionary behavioural genetics and mental disorders
- Dr. Matthew Keller
- Questions and Answers
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45. Audience questions about evolution and medicine
- Prof. Randolph Nesse
- Paediatrics
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46. Evolutionary pediatrics
- Dr. Paul Turke
- Microbiome
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47. Evolution, the microbiome, and human health
- Dr. Joe Alcock
- Archived Lectures *These may not cover the latest advances in the field
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48. The hygiene hypothesis
- Prof. Graham Rook
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49. Mapping motivations: evolutionary health promotion
- Dr. Valerie Curtis
- Dr. Robert Aunger
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50. Evolutionary biology of depression
- Prof. Lewis Wolpert
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51. Evolutionary genetic epidemiology
- Prof. Nicholas Schork
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52. Mental disorders in the light of evolutionary biology
- Prof. Randolph Nesse
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53. Evolution: medicine's missing basic science
- Prof. Randolph Nesse
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54. Environmental effects on human reproduction
- Prof. Gillian Bentley
Printable Handouts
Navigable Slide Index
- Introduction
- Medical vs. evolutionary research
- Gadgil-Bossert model of energy allocation
- Non-invasive methods to study reproductive effort
- Measurements of steroid hormones in saliva
- Evidence of quantitative variation in ovarian function
- Ovarian function and energy availability (1)
- Ovarian function and energy availability (2)
- Energy expenditure in traditional societies
- Steroid hormones: winter vs. monsoon season
- Food availability and ovarian function
- Conception seasonality
- Women of southern Poland
- Variation in ovarian function among Polish women
- Energy expenditure variation in southern Poland
- Ovarian steroid levels and ponderal index (Poland)
- PI, activity level and adult ovarian function
- Reproductive effort in males
- Mating and parenting efforts in men
- Testosterone levels of married vs. unmarried men
- Testosterone levels in business school students
- Pattern of testosterone levels among the Hadza
- High steroid levels and cancer
- The "black box" of Gadgil-Bossert model
- Hormones governing metabolic energy allocation
- Insulin
- Effect of insulin on gonadal steroid production
- Results of the dual action of insulin
- Energy allocation hormones
- Characteristics of energy allocation hormones
- Anabolic processes promoted by the hormones
- Postpartum resumption of ovarian function
- Nursing frequency in traditional societies
- Duration of amenorrhea in traditional societies
- C-peptide levels during lactation period (Toba)
- C-peptide levels and menstrual resumption
- Link between C-peptide levels, BMI and estrogen
- Nursing frequency and menstrual resumption
- Puberty
- Mechanisms of growth and reproductive maturation
- Changes in levels of key parts in growth process
- Birth
- What triggers human parturition?
- Metabolic cross-over
- Changes in fat storage during pregnancy
- Fetus metabolic crisis and labor initiation
- Energy allocation changes in life history transitions
- Energy allocation during postpartum resumption
- Energy allocation during adolescent growth
- Energy allocation during parturition
- Summary
- Acknowledgements
Topics Covered
- The energy allocation model of life history evolution
- Quantitative variation in energy allocation to reproduction
- Endocrine control of qualitative, state transitions in human life history
- Three example transitions: postpartum resumption of ovarian function, puberty, birth
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Ellison, P. (2020, August 16). The endocrinology of human life history transitions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 15, 2025, from https://doi.org/10.69645/FKYM5078.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Peter Ellison has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Reproduction & Development
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. I'm Peter Ellison from the Department of Anthropology at Harvard University.
This is a talk about The Endocrinology of Human Life History Transitions.
0:11
A typical program in medical research
begins with some problem in human health, some pathology.
Consideration of this problem leads to hypotheses regarding
the physiological processes that give rise to the pathology,
and ways in which those processes might be modified.
Data to test these hypotheses are usually derived from westernized urban populations,
such as those in the vicinity of the centers of medical research.
Evolutionary biologists, of whom I am one,
don't follow this familiar paradigm.
Indeed, my research interests do not focus
on human health and disease in any particular way.
I'm interested in human biology in much the same way
that an ornithologist is interested in bird biology.
Disease, although an important part of both bird and human biology,
is after all only a small part of the whole,
something that the ornithologist is happy to leave to the veterinarian.
Rather than starting with questions of pathology,
my research, and that of many other evolutionary human biologists,
starts with questions stemming from evolutionary theory,
questions about the design and function of the human organism.
These questions give rise to hypotheses,
about the physiological processes that express the design,
much as in the medical research model.
But for an evolutionary human biologist,
western urbanized populations do not provide an
adequate or often even in appropriate context for empirical research.
Rather, we seek to understand human biology in
reference to a broad spectrum of human ecologies,
including those of our formative evolutionary past.
Although human biological research is not essentially
motivated by questions of health and disease,
the results which are arrived at by this research paradigm,
often have direct relevance to health and disease.
I will touch on some of these in the course of this talk.