• Principles in Bacterial Pathogenesis
• 43 min
  1. The molecular basis of bacterial pathogenicity: an overview

  • Prof. B. Brett Finlay
• Gram Negative Pathogens
• 50 min
  2. Deciphering shigella invasion of epithelial cells

  • Prof. Philippe Sansonetti
• 43 min
  3. Legionella pneumophila: an intracellular pathogen of phagocytes

  • Dr. Craig Roy
• 57 min
  4. Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease

  • Prof. John Mekalanos
• 34 min
  5. Bordetella pertussis

  • Prof. Alison Weiss
• 37 min
  6. Salmonellae: molecular basis of infection

  • Prof. Samuel Miller
• 43 min
  7. The diversity of Escherichia coli infections

  • Prof. Michael Donnenberg
• 18 min
  8. Bacterial activation of epithelial signaling

  • Prof. Alice Prince
• 48 min
  9. Human pathogenic Yersinia species

  • Prof. James Bliska
• 32 min
  10. From CagA to CagA: the metamorphoses of the Helicobacter pylori's cytotoxin-associated gene A into the cancer-associated gene A

  • Dr. Antonello Covacci
• 46 min
  11. Dental pathogens

  • Prof. Ann Progulske-Fox
• 35 min
  12. Haemophilus

  • Prof. Robert Munson
• Gram Positive Pathogens
• 53 min
  13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model

  • Prof. Pascale Cossart
• 42 min
  14. The war against extensively drug resistant Mycobacterium tuberculosis: intelligence acquisition

  • Prof. William Jacobs
• 48 min
  15. Molecular pathogenesis and prevention of Staphylococcus aureus infections

  • Prof. Olaf Schneewind
• 49 min
  16. Streptococcus pyogenes disease and molecular pathogenesis

  • Prof. P. Patrick Cleary
• Host Responses
• 29 min
  17. Microbial recognition and the immune response

  • Dr. Dana Philpott
• 40 min
  18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions

  • Prof. Vanessa Sperandio
• 47 min
  19. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 56 min
  20. The human indigenous microbiota

  • Prof. David Relman
• 53 min
  21. Human genetics of infectious diseases: the example of bacterial/mycobacterial infections

  • Dr. Laurent Abel
• 47 min
  22. Role of neutrophils in acute lung injury and repair

  • Prof. Gregory Downey
• Preventatives and Therapeutics
• 35 min
  23. Antibiotics and antibiotic resistance

  • Prof. Gerry Wright
• 36 min
  24. Vaccines: a health insurance of the 21st century

  • Prof. Rino Rappuoli
• 41 min
  25. Biodefense vaccines

  • Prof. James Nataro
• Archived Lectures *These may not cover the latest advances in the field
• 39 min
  26. Vaccines in the modern world

  • Prof. Gordon Dougan
• 39 min
  27. Bacterial infection of epithelial signaling

  • Prof. Alice Prince

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Concept through proof of concept
3. Epidemiological observations
4. Methods of investigation in humans
5. Mendelian and complex inheritance
6. Mendelian genetics
7. Invasive pneumococcal disease (IPD)
8. Genetic disorders in the NF-KB signaling pathway
9. IRAK-4/MyD88 deficiencies
10. The genus Mycobacterium
11. MSMD
12. Gene mutations in MSMD
13. IL12R-beta1 deficiency and tuberculosis (TB)
14. Mendelian TB proportion in disseminated forms
15. Investigation of common infectious diseases
16. Tuberculosis and leprosy
17. TB: individual variability in response to infection
18. Complex TB inheritance: candidate genes
19. Complex TB inheritance: major gene
20. TB: genome-wide linkage screen
21. Linkage to chromosome 8q12-q13
22. Leprosy: response to M. leprae
23. Leprosy clinical features
24. Leprosy epidemiology
25. Countries with increasing incidence
26. Difficulties in investigating leprosy
27. Leprosy per se
28. Leprosy linkage analysis (1)
29. Leprosy linkage analysis (2)
30. Family-based association study
31. Primary scan
32. Results of the association study
33. Exact replication in the same population (1)
34. Exact replication in the same population (2)
35. Case-control replication in Northern India (1)
36. Case-control replication in Northern India (2)
37. LTA+80 A allele effect on leprosy susceptibility
38. Case-control replication in Brazil
39. LTA+80 A allele effect in the Brazilian population
40. Age at leprosy diagnosis
41. Performing the analysis by age
42. Concluding remarks on leprosy
43. Continuous spectrum
44. Genetic spectrum depends on age
45. Acknowledgements (1)
46. Acknowledgements (2)
47. Some reviews in the subject

Topics Covered

• General strategy for investigating human genes in infectious diseases
• A continuous spectrum from Mendelian to complex predisposition
• Mendelian predisposition to invasive pneumococcal disease
• Mendelian predisposition to mycobacterial infections including tuberculosis
• Complex predisposition to tuberculosis and leprosy

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Genetics & Epigenetics
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 29, 2009

Financial Disclosures

• Dr. Laurent Abel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.