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1. Introduction
2. Concept through proof of concept
3. Epidemiological observations
4. Methods of investigation in humans
5. Mendelian and complex inheritance
6. Mendelian genetics
7. Invasive pneumococcal disease (IPD)
8. Genetic disorders in the NF-KB signaling pathway
9. IRAK-4/MyD88 deficiencies
10. The genus Mycobacterium
11. MSMD
12. Gene mutations in MSMD
13. IL12R-beta1 deficiency and tuberculosis (TB)
14. Mendelian TB proportion in disseminated forms
15. Investigation of common infectious diseases
16. Tuberculosis and leprosy
17. TB: individual variability in response to infection
18. Complex TB inheritance: candidate genes
19. Complex TB inheritance: major gene
20. TB: genome-wide linkage screen
21. Linkage to chromosome 8q12-q13
22. Leprosy: response to M. leprae
23. Leprosy clinical features
24. Leprosy epidemiology
25. Countries with increasing incidence
26. Difficulties in investigating leprosy
27. Leprosy per se
28. Leprosy linkage analysis (1)
29. Leprosy linkage analysis (2)
30. Family-based association study
31. Primary scan
32. Results of the association study
33. Exact replication in the same population (1)
34. Exact replication in the same population (2)
35. Case-control replication in Northern India (1)
36. Case-control replication in Northern India (2)
37. LTA+80 A allele effect on leprosy susceptibility
38. Case-control replication in Brazil
39. LTA+80 A allele effect in the Brazilian population
40. Age at leprosy diagnosis
41. Performing the analysis by age
42. Concluding remarks on leprosy
43. Continuous spectrum
44. Genetic spectrum depends on age
45. Acknowledgements (1)
46. Acknowledgements (2)
47. Some reviews in the subject

Topics Covered

• General strategy for investigating human genes in infectious diseases
• A continuous spectrum from Mendelian to complex predisposition
• Mendelian predisposition to invasive pneumococcal disease
• Mendelian predisposition to mycobacterial infections including tuberculosis
• Complex predisposition to tuberculosis and leprosy

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Genetics & Epigenetics
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Abel, L. (2009, October 29). Human genetics of infectious diseases: the example of bacterial/mycobacterial infections [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/HCXF6991.
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Publication History

• Published on October 29, 2009

Financial Disclosures

• Dr. Laurent Abel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.