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Printable Handouts
Navigable Slide Index
- Introduction
- Concept through proof of concept
- Epidemiological observations
- Methods of investigation in humans
- Mendelian and complex inheritance
- Mendelian genetics
- Invasive pneumococcal disease (IPD)
- Genetic disorders in the NF-KB signaling pathway
- IRAK-4/MyD88 deficiencies
- The genus Mycobacterium
- MSMD
- Gene mutations in MSMD
- IL12R-beta1 deficiency and tuberculosis (TB)
- Mendelian TB proportion in disseminated forms
- Investigation of common infectious diseases
- Tuberculosis and leprosy
- TB: individual variability in response to infection
- Complex TB inheritance: candidate genes
- Complex TB inheritance: major gene
- TB: genome-wide linkage screen
- Linkage to chromosome 8q12-q13
- Leprosy: response to M. leprae
- Leprosy clinical features
- Leprosy epidemiology
- Countries with increasing incidence
- Difficulties in investigating leprosy
- Leprosy per se
- Leprosy linkage analysis (1)
- Leprosy linkage analysis (2)
- Family-based association study
- Primary scan
- Results of the association study
- Exact replication in the same population (1)
- Exact replication in the same population (2)
- Case-control replication in Northern India (1)
- Case-control replication in Northern India (2)
- LTA+80 A allele effect on leprosy susceptibility
- Case-control replication in Brazil
- LTA+80 A allele effect in the Brazilian population
- Age at leprosy diagnosis
- Performing the analysis by age
- Concluding remarks on leprosy
- Continuous spectrum
- Genetic spectrum depends on age
- Acknowledgements (1)
- Acknowledgements (2)
- Some reviews in the subject
Topics Covered
- General strategy for investigating human genes in infectious diseases
- A continuous spectrum from Mendelian to complex predisposition
- Mendelian predisposition to invasive pneumococcal disease
- Mendelian predisposition to mycobacterial infections including tuberculosis
- Complex predisposition to tuberculosis and leprosy
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Talk Citation
Abel, L. (2009, October 29). Human genetics of infectious diseases: the example of bacterial/mycobacterial infections [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/HCXF6991.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Laurent Abel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Human genetics of infectious diseases: the example of bacterial/mycobacterial infections
Published on October 29, 2009
53 min
A selection of talks on Genetics & Epigenetics
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