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- Structure of the blood-brain barrier
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1. The blood-brain barrier in Alzheimer’s disease
- Dr. Anika Hartz
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2. Tanycytes allow a tight BBB in the median eminence
- Prof. Esteban Rodriguez
- Dr. Juan Luis Blazquez
- Dr. Montserrat Guerra
- Nutrient transport
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3. Blood-brain barrier ion transport
- Prof. Martha O'Donnell
- Peptides and proteins
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4. Ingestive peptides
- Prof. William Banks
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5. Blood-brain barrier in health and disease
- Prof. Thomas Davis
- Overcoming the blood-brain barrier obstacle
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6. Expression vs. function of ABC transporters at the blood-brain barrier
- Prof. Jean-Michel Scherrmann
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7. The blood-brain barrier and CNS drug development
- Dr. Danica Stanimirovic
- Diseases involving the blood-brain barrier
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9. Inflammation and immune cell entry to the central nervous system
- Prof. Serge Rivest
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11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development
- Prof. Ryszard Pluta
- Latest Developments in the Field
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12. MRI approaches for neurovascular imaging
- Dr. Rick Dijkhuizen
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13. Brain-gut interactions in obesity 1
- Prof. Weihong Pan
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14. Brain-gut interactions in obesity 2
- Prof. Weihong Pan
- Archived Lectures *These may not cover the latest advances in the field
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15. Neurotrophins and the BBB
- Prof. Weihong Pan
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16. Vasoactive peptides and the blood-brain barrier
- Prof. Maria Deli
- Prof. Bela Kis
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17. In vivo systems
- Prof. Quentin Smith
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18. CNS-drug design
- Prof. Quentin Smith
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20. Stroke and the BBB
- Prof. Marilyn Cipolla
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21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings
- Prof. Norman Saunders
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22. Barrier mechanisms in the developing brain: protection or vulnerability?
- Prof. Norman Saunders
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23. In vitro models of the blood-brain barrier
- Prof. Pierre-Olivier Couraud
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24. Glucose transport across the blood-brain barrier
- Prof. Luc Leybaert
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25. The blood-brain barrier and brain tumors
- Dr. Olaf van Tellingen
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26. Cellular composition of the blood-brain barrier
- Prof. N. Joan Abbott
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27. Features of mammalian CNS barrier systems
- Prof. Conrad Johanson
Printable Handouts
Navigable Slide Index
- Introduction
- Barrier mechanisms in the developing brain
- The brain barriers - overview
- Claude Bernard - the brain's internal environment
- Alcian blue stain of gut, eye and brain
- Paul Ehrlich
- Edwin Goldmann
- Max Heinrich Lewandowsky
- Tight junctions and their function in the BBB
- Hugh Daveson
- The brain barriers in the embryo
- Outline
- Brain development - different species
- Trypan blue dye of fetal guinea pig
- Dye injection to the CSF, Pig 9mm CRL embryo
- Stern - Dye injection in newborn animals
- Newborn mouse injected with Trypan blue
- Colloids and crystalloids dyes
- Freeze fractures in brain development
- Freeze fractures of blood vessel tight junctions
- Tight junctions permeability in developing brain
- Biotin labeled molecules for permeability testing
- Junctions are functionally tight in early stages (1)
- Junctions are functionally tight in early stages (2)
- Junctions are functionally tight in early stages (3)
- A possible trans-cellular route of entry
- Tightness of blood vessels in developing brain
- P1 Monodelphis, stained with anti-albumin
- Mechanisms of barriers induction
- Molecular basis of induction process
- Radio-labeled permeability markers experiments
- The sheep placenta
- Marker levels after IV injection - plasma and CSF
- CSF:plasma ratio
- Experiments with marsupial new born
- Brain development of a newborn opossum
- CSF:plasma ratio in opossum (1)
- Brain:plasma ratio in opossum
- CSF turnover
- CSF secretion in the developing brain
- CSF:plasma ratio in opossum (2)
- Establishment of ion gradients CSF:plasma
- Ion gradient in brain development
- Chloride gradient in rats
- Effective barrier mechanisms in developing brain
- Adult ion transfer
- Transporter expression in embryo choroid plexus
- AQP1 - lateral ventricle (rat)
- Lateral ventricular volume
- High concentration of proteins in CSF
- Protein concentration in CSF (rat)
- High protein levels exert an osmotic effect
- Strap junctions
- Freeze fractures of strap and tight junctions
- TEM of strap and tight junctions
- Protein positive epithelial cells, LV choroid plexus
- P6 M. domestica: albumin in choroid plexus
- Expansion of the ventricular system
- Summary
- Acknowledgements
- References
Topics Covered
- The brain barriers
- Historical perspective
- Morphology of cerebral blood vessels and choroid plexus in the development brain
- Are tight junctions functionally tight?
- Ion and water transfer mechanisms
- Origin and significance of high CSF protein concentration in embryos
- CSF-brain barrier in the developing brain
Talk Citation
Saunders, N. (2009, November 19). Barrier mechanisms in the developing brain: mechanisms and misunderstandings [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 8, 2024, from https://doi.org/10.69645/XZBH4186.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Norman Saunders has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Barrier mechanisms in the developing brain: mechanisms and misunderstandings
A selection of talks on Neuroscience
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