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1. Introduction
2. Why do we have NK cells?
3. NK cells are important in viral immunity
4. NK cells participation during a viral infection
5. NK cell responses to interferons and cytokines
6. NK cells are activated as bystanders
7. NK cells control replication of MCMV
8. NK MCMV control - in certain genetic backgrounds
9. NK resistance segregates as a single locus
10. MCMV resistance maps to the "NK complex"
11. Ly49 receptors - background
12. Inhibitory and activating Ly49 receptors
13. MCMV genome
14. Ly49H ligand = MCMV m157
15. Direct recognition: NK recognition of viral ligands
16. Ly49H is the receptor for m157 glycoprotein
17. m157 binds Ly49H+ NK - not Ly49H- NK
18. MCMV results in m157 loss-of-function
19. Why did m157 evolve and why is it maintained?
20. Ly49 genes are polymorphic
21. Ly49H-relatives
22. m157 binds to NK cells in 129/J mice
23. m157 binds to inhibitory Ly49I(129) in 129/J mice
24. m157 structure
25. Virus-driven NK receptor evolution?
26. NK response to MCMV - direct and indirect
27. Do other Ly49 receptors protect against MCMV?
28. Ly49 genes in different mouse strains
29. MA/My mice are MCMV-resistant
30. MA/My resistant requires 2 genes
31. NK recognition of host-encoded ligands
32. NKG2D receptor and DAP11
33. NKG2D ligands
34. CMV effectively neutralize NKG2D recognition
35. MCMV blocks expression of NKG2D ligands
36. NK cells and cytomegalovirus
37. NK cells and poxviruses
38. NK cells are required during early infection
39. Mousepox infection induces NKG2D ligands
40. Blocking NKG2D renders B6 mice susceptible
41. Blocking NKG2D on NK increase viral titers
42. NK cell depletion impairs T cell responses
43. NK cells and mousepox - summary
44. Natural cytotoxicity receptors
45. NKp46 deficient mice are more susceptible to flu
46. NK cells in human viral immunity
47. NK complex in mouse and human
48. KIR genes have replaced Ly49 in humans
49. Association of KIR genes with viral infection
50. NK cells implicated in other viral infections
51. Acknowledgements
52. References

Topics Covered

• Why do we have NK cells?
• Importance in viral immunity
• NK cell responses to interferon alpha/beta and cytokines induced by virus
• Control of replication in viruses
• Mouse cytomegalovirus (MCMV)
• Ly49 receptors
• Inhibitory and activating Ly49 receptors
• Direct recognition of virus-infected cells by NK cells
• Ly49H is the receptor for m157 MCMV glycoprotein
• Why did m157 evolve and why is it maintained?
• Ly49 genes are polymorphic
• Virus-driven NK receptor evolution
• Is Ly49H an exception or do other activating Ly49 receptors protect against MCMV?
• Direct recognition of virus-infected cells by NK cells
• NK cells and cytomegalovirus
• NK cells and poxviruses
• Natural cytotoxicity receptors
• NK cells in human viral immunity
• Association of KIR genes with viral infection

Links

Series:

• Natural Killer Cell Biology

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on September 23, 2009
• Archived on October 31, 2021

Financial Disclosures

• There are no commercial/financial matters to disclose.